Chromosome analyses of bone marrow cells prepared by the direct method were carried out on 32 male patients, who had no primary haematological disease. One patient was found to have a pericentric inversion of the Y chromosome, which was also present in a skin fibroblast culture and in a lymphocyte culture. Three cases were found to have a high percentage of bone marrow cells with a 45,X chromosome constitution and one case had a 45,X?Yor Gcell line. The high degree ofaneuploidy was not found on examination of cells from leucocyte cultures. This observation is discussed in relation with other similar findings in patients with haematological diseases. The remaining 27 patients had a normal male karyo-
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