BACKGROUND: Chronic eosinophilic rhinosinusitis with nasal polyps (CRSwNP eosinophilic) is characterised by the formation of benign and bilateral nasal polyps. We aimed to compare the effectiveness of azithromycin as an immunomodulator with the use of a placebo in patients presenting with CRSwNP concomitant with asthma and aspirin intolerance after 3 months of treatment and at a 1-year follow-up. METHODOLOGY: We performed a randomised, double-blind, placebo-controlled trial. Patients received 500 mg azithromycin orally three times/week for 12 weeks. Improvement was evaluated by staging, the Sino-Nasal Outcome Test (SNOT-22), and nasal polyp biopsy. Data collected at pretreatment and 3 months posttreatment were compared. Quality of life was evaluated at the 1-year follow-up. RESULTS: Twenty-seven and 21 patients were treated with azithromycin and a placebo, respectively. The medication was well tolerated overall. Twenty patients (74%) in the azithromycin group and three patients (14%) in the placebo group were not refer- red for surgery at the end of the 3-month treatment. Regarding subjective improvement, there was a median decrease only in the azithromycin group, and the between-group difference was significant. SNOT-22 improvement was maintained in the azithromy- cin group at the 1-year follow-up. CONCLUSIONS: Azithromycin could be considered a therapeutic option for patients presenting with CRSwNP concomitant with asthma and aspirin intolerance.
Knowing the properties and clinical indications of each material ensures that the dental surgeon can use techniques that guarantee better results for dental prostheses. This study aims to evaluate the dimensional stability of an irreversible hydrocolloid modified by the addition of silicone by condensation. During this evaluated the dimensional distortion of irreversible hydrocolloids according to conditioning time, for four commercial brands, being: Avagel (Dentsply), Hydrogum 5 (Zhermack Spa) and Jeltrate Plus (Dentsply) and Avagel plus Condensation Silicone (Zetaplus [Zhermach]). They were placed in a container with 100% humidity, and the following requirements were evaluated: weight, height, and length of the three groups during the following times: immediately, 24 hours, 48 hours, 72 hours, and 120 hours. All materials evaluated showed adequate dimensional stability within the initial 72 hours. The addition of condensation silicone to the irreversible hydrocolloid mixture did not improve the dimensional stability of the material.
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