Azithromycin for the Treatment of Eosinophilic Nasal Polyposis: Clinical and Histologic Analysis

Oliveira, Isamara Simas de; Crosara, Paulo Fernando Tormin Borges; Cassali, Geovanni Dantas; Reis, Diego Carlos dos; Rodrigues, Danilo Santana; Nunes, Flávio Barbosa; Guimarães, Roberto Eustáquio Santos

doi:10.2500/ar.2016.7.0160

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…After inducing nasal cavity anaesthesia with cotton soaked in 2% neotonocaine, polyps measuring 5 × 2 mm in size were removed using EXPLORENT (Olympus America Inc., Center Valley, PA, USA) forceps, avoiding maceration of the tissue. Complementary tests were requested, including an electrocardiogram, complete blood cell count, and hepatic staging, which has the advantage of identifying polyp locations in three-dimensional space, and classifies polyp locations in regions other than the middle meatus (15,17) . The method is exclusively based on nasal endoscopy (nasofibroscopy).…”

Section: General Designmentioning

confidence: 99%

“…The cellularity was analysed by exploring five fields of the optical microscope with 400× magnification, as suggested by Ingels et al (26) . The inflammatory infiltration was semiquantitatively evaluated following well-defined criteria (15,18) and classified according to its distribution and intensity. The distribution was characterised as focal, multifocal, or diffuse depending on the presence of one to three or more than three inflammatory foci and uniformly distributed inflammatory cells.…”

Section: General Designmentioning

confidence: 99%

“…The use of macrolides as immunomodulators is important in this context (13,14) . In our previous work, we used azithromycin (15) ; the study design precluded definite conclusions on medication efficacy, but promising effects were observed in patients with extensive nasal polyposis.…”

Section: Introductionmentioning

confidence: 99%

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Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial

Oliveira

Guimaraes

Pêgas

et al. 2020

Rhin

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BACKGROUND: Chronic eosinophilic rhinosinusitis with nasal polyps (CRSwNP eosinophilic) is characterised by the formation of benign and bilateral nasal polyps. We aimed to compare the effectiveness of azithromycin as an immunomodulator with the use of a placebo in patients presenting with CRSwNP concomitant with asthma and aspirin intolerance after 3 months of treatment and at a 1-year follow-up. METHODOLOGY: We performed a randomised, double-blind, placebo-controlled trial. Patients received 500 mg azithromycin orally three times/week for 12 weeks. Improvement was evaluated by staging, the Sino-Nasal Outcome Test (SNOT-22), and nasal polyp biopsy. Data collected at pretreatment and 3 months posttreatment were compared. Quality of life was evaluated at the 1-year follow-up. RESULTS: Twenty-seven and 21 patients were treated with azithromycin and a placebo, respectively. The medication was well tolerated overall. Twenty patients (74%) in the azithromycin group and three patients (14%) in the placebo group were not refer- red for surgery at the end of the 3-month treatment. Regarding subjective improvement, there was a median decrease only in the azithromycin group, and the between-group difference was significant. SNOT-22 improvement was maintained in the azithromy- cin group at the 1-year follow-up. CONCLUSIONS: Azithromycin could be considered a therapeutic option for patients presenting with CRSwNP concomitant with asthma and aspirin intolerance.

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Section: General Designmentioning

confidence: 99%

Section: General Designmentioning

confidence: 99%

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Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial

Oliveira

Guimaraes

Pêgas

et al. 2020

Rhin

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Perfil epidemiológico da morbimortalidade da Covid-19 no Estado do Piauí: uma atualização do cenário atual

Silva

et al. 2020

RSD

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O novo Coronavírus foi definido como SARS-CoV-2 no fim de 2019. Ele é responsável pela a doença classificada como COVID-19. O presente estudo teve como objetivo discutir os óbitos provocados pela covid-19 no estado do Piauí durante a pandemia, e sua correlação com as comorbidades associadas aos pacientes e sua faixa etária. Trata-se de uma pesquisa descritiva, executada a partir do levantamento epidemiológico dos casos e óbitos da Covid-19 no Estado do Piauí. Foi analisada a faixa etária, comorbidades e fatores de risco identificados entre os óbitos, onde a partir desses dados, foi calculado a letalidade e plotados em tabelas. O estado do Piauí apresenta 10.153 mil casos confirmados, tendo a capital Teresina, com o maior número, com 43% dos casos seguido da cidade litorânea de Parnaíba com 13%, Barras 4%, Campo maior 3% e Picos 3%. Teresina ainda apresentou o maior número de óbitos com 196 mortes, seguido de Parnaíba (n=31), Barras (n=8), Campo maior (n=7), Picos, Esperantina e Piripiri (n=6). As cardiopatias tiveram a maior frequência nos casos de óbitos por Covid-19, com 48,61% dos casos, seguido da diabetes com 23,61%, DNC ou DNM 4,63%, Obesidade 3,7%. A faixa etária de 70 a 79 anos a mais acometida com 30%, seguido de 80 anos ou mais com 26,67%. Assim, pode-se inferir o quão é imprescindível o desenvolvimento estrutural da saúde pública no Piauí, sobretudo, nos centros emergentes, bem como a preservação prioritária das pessoas que possuem comorbidades e com faixa etária alta.

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The Role of Upper Airway Microbiome in the Development of Adult Asthma

et al. 2021

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Azithromycin for the Treatment of Eosinophilic Nasal Polyposis: Clinical and Histologic Analysis

Abstract: ABSTRACT

Cited by 3 publications

References 29 publications

Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial

Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial

Perfil epidemiológico da morbimortalidade da Covid-19 no Estado do Piauí: uma atualização do cenário atual

The Role of Upper Airway Microbiome in the Development of Adult Asthma

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