EEF1D (eukaryotic translation elongation factor 1δ) is a subunit of the elongation factor 1 complex of proteins that mediates the elongation process during protein synthesis via enzymatic delivery of aminoacyl-tRNAs to the ribosome. Although the functions of EEF1D in the translation process are recognized, EEF1D expression was found to be unbalanced in tumours. In the present study, we demonstrate the overexpression of EEF1D in OSCC (oral squamous cell carcinoma), and revealed that EEF1D and protein interaction partners promote the activation of cyclin D1 and vimentin proteins. EEF1D knockdown in OSCC reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes, including cell invasion. Taken together, these results define EEF1D as a critical inducer of OSCC proliferation and EMT.
AIMTo elucidate the profile of the salivary proteome.METHODSUnstimulated whole mouth saliva was collected from 30 volunteers [15 proliferative verrucous leukoplakia (PVL) patients and 15 controls] and proteins were submitted for mass spectrometry-based proteomics using the discovery approach, followed by analyses of variance and logistic regression tests.RESULTSA total of two hundred and eighty-three proteins were confidently identified in saliva. By combining two low abundance proteins from the PVL group, angiotensinogen (AGT) and dipeptidyl peptidase 1 (DPP1), a model for group differentiation was built with a concordance index of 94.2%, identifying both proteins as potential etiologic biomarkers for PVL.CONCLUSIONThis study suggests that both AGT and DPP1 may be involved in developmental mechanisms of PVL.
The use of cosmetic fillers agents in orofacial region has become more often used for esthetic concern. Although adverse effects are rare, some patients may develop foreign body reaction to such fillers. Hyaluronic acid (HA) is a biomaterial in the spotlight, because it is normally present in several tissues of human body. The aim of this study was to report a case of a 54-year-old white woman with granulomatous reaction to the HA located in the lips. In addition, a review of the English-language literature of all previously described cases of this condition in oral and perioral region was performed. The location, clinical features, symptoms, time between injection and reaction, type of treatment and treatment outcome of 17 cases were summarized. The clinical and histopathological examination along with a detailed history about this condition is very important to management of patients with nodular lesions in maxillofacial region.
BackgroundJaw pseudocysts are benign osseous lesions of unclear etiology. Among these, the simple bone
cyst (SBC) and aneurysmal bone cyst (ABC) are intriguing bone pathologies still rarely studied
together. This retrospective study aimed to present the long-term case series of patients with
jaw pseudocysts focusing on the clinical, radiographic, and transoperative aspects.Material and MethodsA retrospective case series of patients with SBC and ABC was performed. Clinical,
radiographic, and transoperative aspects of both pseudocysts were reviewed from the
histopathological archives of 20,469 cases between 1959-2012. All descriptive data were
summarized.ResultsOf 354 (15.25%) bone pathologies, 54 cases of jaw pseudocysts were found, with 42 (11.86%)
SBC and 12 (3.39%) ABC cases. For both lesions, most of the sample were young Caucasian women
with an asymptomatic posterior mandible lesion with undetermined time of evolution and none
trauma history. A unique radiolucent scalloped lesion presenting an empty cavity were also
observed for both conditions. However, some atypical findings were found for SBC including:
the expansion of bone cortical, tooth resorption, displacement of the mandibular canal, and
recurrence. The absence of painful symptoms and the lack of classical blood-filled cavity were
observed in some cases of ABC.ConclusionsThe SBC and ABC are bone pathologies with few retrospective studies, no previous studies on
the two conditions, varied nomenclature, and atypical aspects in some cases. Therefore, the
knowledge of clinical, imaging, and transoperative features of such pseudocysts are clinically
valuable as diagnosis hypothesis of radiolucent lesions of the jaws.
Key words:Simple bone cyst, aneurysmal bone cyst, pseudocysts, jaws.
Odontogenic keratocysts make up 4%–12% of all odontogenic cysts. Most cysts are
sporadic but sometimes they arise in the context of basal cell nevus syndrome
(Gorlin syndrome). Most odontogenic keratocysts arise in the posterior region of
the mandible, but they can occur anywhere in the jaw. In rare instances, they
are located peripherally in the gingiva. Even more rare, they are found in the
soft tissues of the mouth. There have been a few case reports and small case
series of such peripheral odontogenic keratocysts. Some controversy exists as to
whether these truly represent a peripheral counterpart of the intraosseous
odontogenic keratocysts and if their origin is at all odontogenic. We hereby
present two cases of peripheral odontogenic keratocysts, both being located in
the soft tissue of the buccal mucosa, and review the literature on peripheral
odontogenic keratocysts.
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