Evaporative‐based detectors are a new generation of instruments, which provide a universal response for a wide variety of compounds or their families whose determination by other conventional detection systems is limited by different reasons. Both evaporative light scattering detector (ELSD) and corona‐charged aerosol detector (C‐CAD) have been recognized as global response detectors in liquid and supercritical chromatographies. Their advantage over optical or electrochemical detectors is that they do not require from the analytes to present special physicochemical properties. The evaporative‐based detectors nebulized the mobile‐phase/liquid stream effluent, producing analyte particles that are optically detected through the scattered light in the case of ELSD or by charge transfer in the case of the C‐CAD. The foundation of the detection and the main applications of these detectors will be deeply commented in this article. Moreover, a comparison with conventional detectors (ultraviolet/visible (UV/VIS), refractive index (RI), and mass spectrometers (MSs)) is included. In the light of the bibliography available on this topic, future applications of and perspectives on the use of these detectors can also be anticipated.
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