Evaporative‐Based Detectors as Global Response Instruments

Abstract

Evaporative‐based detectors are a new generation of instruments, which provide a universal response for a wide variety of compounds or their families whose determination by other conventional detection systems is limited by different reasons. Both evaporative light scattering detector (ELSD) and corona‐charged aerosol detector (C‐CAD) have been recognized as global response detectors in liquid and supercritical chromatographies. Their advantage over optical or electrochemical detectors is that they do not require from the analytes to present special physicochemical properties. The evaporative‐based detectors nebulized the mobile‐phase/liquid stream effluent, producing analyte particles that are optically detected through the scattered light in the case of ELSD or by charge transfer in the case of the C‐CAD. The foundation of the detection and the main applications of these detectors will be deeply commented in this article. Moreover, a comparison with conventional detectors (ultraviolet/visible (UV/VIS), refractive index (RI), and mass spectrometers (MSs)) is included. In the light of the bibliography available on this topic, future applications of and perspectives on the use of these detectors can also be anticipated.

Traveling-Wave-Based Electrodynamic Switch for Concurrent Dual-Polarity Ion Manipulations in Structures for Lossless Ion Manipulations

“…Ion mobility spectrometry (IMS) is becoming an indispensable tool for the analysis of ions in the gas phase, with applications ranging from simple analytical systems used in security applications [1][2][3][4] to the analysis of complex biological samples in omics research in conjunction with mass spectrometry. [5][6][7] IMS has also shown promise as an attractive alternative to traditional separation techniques (e.g., liquid chromatography). 8 Furthermore, IMS-based separations can provide additional insight into the characterization of a given analyte based on the relationship between an ion's mobility (the basis on which ions are separated in the gas phase) and its rotationally averaged ion-neutral collisional cross section, established by the Mason-Schamp relationship.…”