The short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.

RESUMOObjetivo: verificar os efeitos da perda de peso na densidade mineral óssea (dMO) de adolescentes obesos submetidos a intervenção com base em dieta hipocalórica e orientações durante nove meses. Métodos: realizaram-se avaliações da antropometria, da composição corporal, da dMO e do consumo alimentar. Resultados: Participaram do estudo 55 adolescentes, 78,2% meninas, com média de 16,6 (1,4) anos. destes, 44,4% não apresentaram redução do peso. O grupo que respondeu à intervenção apresentou média de perda de peso de 6,2% (4,6) do peso inicial. Houve aumento significativo da dMO e conteúdo mineral ósseo (cMO) entre os adolescentes não-respondedores e aumento do cMO e área óssea entre os respondedores, associados, principalmente, com as alterações da composição corporal com o ganho ou a perda de peso. Conclusão: O aumento da massa óssea mesmo com a perda de peso demonstrou que o emagrecimento não ter efeito negativo do emagrecimento e denota provável contribuição da melhora dos hábitos alimentares na aquisição óssea de adolescentes. Objective: to verify the effects of weight loss on bone mass of obese adolescents submitted to a nutritional intervention based on a hypocaloric diet and nutritional advice over a nine-month-period. Methods: Anthropometry, body composition, BMd and dietary intake were evaluated. Results: Fifty-five adolescents, 78.2% females, within an average age of 16.6 (1.4) years old participated in the study. Sixteen participants who completed the study did not lose weight. the group that adhered to the nutritional intervention had a mean weight loss of 6.2 (4.6)% baseline. there was a significant increase in total BMd and bone mineral content (BMc) in those adolescents who did not lose weight, while increased BMc and bone area were verified in participants who lost weight, mainly when associated with body composition alterations while changing weight. Conclusion: the increment in bone mineral density, even throughout weight loss, has showed no negative effect on bone mass and has also emphasized the importance of nutritional improvement in total bone mass during adolescence. (Arq Bras Endocrinol Metab 2008; 52/6:1001-1008)

Objective: To evaluate the bone mineral density (BMD) and to relate it to the food intake and body composition of adolescent runway models.Methods: Cross-sectional study evaluating 33 models and 33 nonmodels aged from 15 to 18 years, paired by age and body mass index (BMI). BMD of spine (L1-L4) was evaluated using the dual-energy X-ray absorptiometry technique (Lunar  DPX Alpha), and body composition was assessed by mean of plethysmography. Food intake was evaluated by a 3-day-food record. Results:The subjects' mean age was 16.75±1.04 years, and 24% had BMI below ideal value for their age. BMD values (g/cm 2 ) were similar between models (1.108±0.080) and non-models (1.096±0.102) (p > 0.05), and 6% of the participants had low BMD for age. We found that the mean energy intake was lower among models as compared to non-models (1,480.93±582.95 vs. 1,973.00±557.63 kcal) (p < 0.05) and that most of the adolescents in both groups presented an inadequate consumption of micronutrients, with emphasis to the low calcium intakes. There was only significant correlation between BMD and lean body mass (kg) (r = 0.362 for models and r = 0.618 for non-models) (p < 0.05). Conclusion:Although no association was found between BMD, BMI, and intake of nutrients which are important for the bone mineralization process, inadequacies of food intake have an adverse influence on the acquisition of bone mass, which is more effective at this stage of life.J Pediatr (Rio J). 2009;85(6): 503-508: Adolescents, bone mineral density, nutritional status, dietary intake. ResumoObjetivo: Avaliar a densidade mineral óssea (DMO) e relacioná-la com a ingestão alimentar e composição corporal de adolescentes modelos de passarela.Métodos: Estudo transversal avaliando 33 modelos e 33 não modelos de 15 a 18 anos pareadas por idade e índice de massa corporal (IMC). A densidade mineral óssea da coluna (L1-L4) foi avaliada por meio da técnica da absorciometria de feixe duplo de energia (Lunar  DPX Alpha), e a composição corporal, pela técnica de pletismografia. A ingestão alimentar foi avaliada por meio do registro alimentar de 3 dias.Resultados: A média de idade das adolescentes foi de 16,75±1,04 anos, sendo que 24% apresentaram IMC abaixo dos valores ideais para a idade. Não houve diferença de DMO entre modelos (1,108±0,080 g/cm 2 ) e não modelos (1,096±0,102 g/cm 2 ) (p > 0,05), sendo identificada uma porcentagem de 6% de baixa DMO para a idade. Observou-se que a média de ingestão de energia foi menor entre as modelos em comparação às adolescentes não modelos (1.480,93±582,95 versus 1.973,00±557,63 kcal) (p < 0,05) e que a maioria das adolescentes de ambos os grupos apresentou consumo inadequado de micronutrientes, ressaltando-se a baixa ingestão de cálcio. Verificou-se correlação significativa da DMO apenas com a massa magra (kg) (modelos r = 0,362 e não modelos r = 0,618; p < 0,05).Conclusão: Apesar de não ter sido encontrada associação entre a DMO, o IMC e a ingestão de nutrientes importantes no processo de mineralização óssea, as inadequações ...

Germfree (GF) and conventional (CV) mice were fed on diets containing 4.4, 13.2 or 26.4% of protein (weight/weight). CV mice fed on low protein diet did not gain weight during four weeks, whereas the protein deficient diet did not affect the growth of GF mice. After four weeks on these diets, the mice were inoculated with 5 x 10(3) trypomastigotes of Trypanosoma cruzi. The protein deficiency affected less the GF than the CV mice, according to the following parameters: weight gain, hemoglobin, plasma protein and albumin levels and water and protein contents of the carcass. Infection with T. cruzi produced a significant decrease in hemoglobin levels, red blood cell count, and water and protein contents in the carcass. This decrease was more pronounced in the GF mice. Histopathologically, there was no difference between the treatments in animals with the same microbiological status (GF or CV). However, the disease was more severe in the GF than in the CV mice.

Objective: To investigate whether levels of autoantibodies to oxidized LDL (anti-oxLDL) in the plasma of adolescents correlates with their anthropometric measurements and lipid profiles. Methods:The study enrolled 150 adolescents aged between 10 and 15 years, recruited from the obesity clinic at Universidade Federal de São Paulo (SP) and from public schools in Piracicaba, SP, Brazil. Anthropometric measurements such as body mass index and waist and arm circumferences were used to classify the adolescents as having healthy weight, overweight or obesity. Colorimetric enzymatic methods were used for biochemical lipid profile analysis and ELISA was used to determine anti-oxLDL autoantibody levels.

The reestablishment of the ratio weight/height in early undernourished girls is also useful to indicate lack of limitation of functional capability to perform physical exercises.

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