Patients with long-term effects of coronavirus disease, the so-called “long-term COVID-19 syndrome” (long-COVID-19) after SARS-CoV-2 infection, have a postponed recovery lasting from 4 weeks and up to six months, spread worldwide. Physiological predictors based on human blood biomarkers and host-virus responses to SARS-CoV-2 are still unknown. There is growing evidence about the impact of micronutrients on improving lymphocyte proliferation and their essential roles for a functioning human immune system and regulating metabolic health. This paper aims to review information about micronutrients in patients with SARS-CoV-2 infection that determines long-COVID-19 outcomes and highlight the importance of diagnostics in predictors of long-COVID-19. We reviewed articles returned from searches on PubMed/SCOPUS/Web of Science/ EMBASE databases using a combination of terms “long COVID-19”, “long-term effects of COVID-19”, “post-COVID-19 symptoms”, “COVID-19 associated stress”, “micronutrients”. Evidence indicates the relationship between lymphocyte proliferation improving micronutrient level and long-COVID-19 induction. Zinc, selenium, iron, manganese have an immunomodulatory function in innate and adaptive immune responses to viral infection. Anti-inflammatory functions of Vits A and B groups include the regulation of lymphocyte proliferation and metabolic health. Further research using sampling and artificial intelligence-assisted algorithms could assist in the recognition of the correlation of micronutrients and long-COVID-19 clinical outcomes

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Social distancing related to the coronavirus disease (COVID-19) pandemic caused by SARS COV2 is an important precautionary measure, implemented by WHO approximately 1 year ago. At the same time, it is a large-scale stressor that has led to multiple changes in the lifestyle around the world. In this crisis, the well-being and health of medical students who belong to the individuals with a high risk of distress in the population are very important for society. The purpose of this research is to study the impact of COVID-19-related stay-at-home policy, social isolation, online academic learning, and working on the medical students' lifestyle and well-being focusing on their self-perception of telecommunication technologies, social media, as well as on the psychophysiological state, and eating behavior of medical students of Danylo Halytsky Lviv National Medical University (LNMU). Methods. A prospective, cohort study was carried out on 273 medical students of the LNMU via an anonymous online survey using Google Forms. 273 people of different ethnicities answered the original questionnaire, which includes: 1) general questions (age, gender, ethnicity, family, education, work, and economic status); 2) issues related to the use of social media; 3) questions about the impact of social distancing on lifestyle; 4) the scale of stress perception. Results: The cohort for the study consisted of 166 women and 107 men in the following age groups: from 17 to 24 — 92 %, 25–31 — 4 %, 35–44 — 2 %, and over 45 years — 2 %. Ethnic groups included Asian — 47 %, Caucasian — 41 %, African — 7 %, Hispanic — 3 %, and multiracial people — 2 %. Social exclusion during COVID-19 was found to be caused by a change in the use of social media, more time spent on using them by all respondents. Among these, 88 % acknowledge that social media have a great impact and 71 % of responders learn basic information about the pandemic via social media. However, 52 % doubt the reliability of the information. The feeling of anxiety, panic, which characterized the perception of stress caused by information on social media, was reported by 56 % of respondents. Almost all respondents changed their lifestyle, which was characterized by physical inactivity and changed eating behavior. About 60 % of respondents reported overeating in the evening and at night (19:00 — 5:00) and almost half of all respondents reported weight gain in the last year. All respondents know about the benefits of physical activity to overcome signs of psycho-emotional stress, but only about 10 % of respondents exercise regularly. There were no differences in the responses from students belonging to the Caucasian group or other ethnicities. Conclusions. The lifestyle of student youth, their eating behavior, and psycho-emotional state are being modified during COVID-19. Social media is an important informative factor in the context of social exclusion and the fight against chronic stress

Aim Multifaceted long COVID caused by SARS-COV-2 affects all populations in the World and takes priority over any other research topics for health care. The purpose of study is to identify physiology-centered risks, prevalence, symptoms and laboratory findings in patients with long COVID in Ukraine. Methods A prospective, cohort study was carried out on 332 patients with long COVID after 4 weeks and more after acute infection COVID-19 from Jul 1, 2021, to Jul 1, 2022. Physiology-centered risks related to age, gender, body mass index (BMI), marital status and educational capacity, smoking, lifestyle, physical activity, and laboratory findings (before disease), and symptom distribution were analyzed. Results The cohort for the study consisted of 166 females and 107 males (mean age = 42; including young 18 (5.4%) and middle- and old-aged adults 314 (96.4%)). Increased BMI was in 61%, and less physical activity—65%. There were 4 clusters of symptoms related to physical, neurocognitive, pulmonary, and pain conditions. 95% of participants had ≥ 3 symptoms. The most common symptoms were fatigue (90%), muscular pain (85%), anosmia (70%), hair loss (70%), sleep disorders (70%), dyspnea (30%), and brain fog (25%). Among laboratory finding increased CRP (92.6%) and fibrinogen (82.7%) dominated. There are no differences between hospitalized and non-hospitalized patients in distribution symptoms. Conclusions The prevalence of long COVID is 23%, and its physiology-centered risk factors are related to age more 38 years, female sex, unhealthy lifestyle, increased BMI, and increased inflammatory markers during COVID-19. The most common symptoms are associated with neurocognitive and pain clusters.

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