SummaryThe preparation of block polymer surface-active agents derived solely from propylene oxide and ethylene oxide is described. The physical properties of a rionionic surfactant of 12,500 molecular weight, Pluronic F-127, are presented.The preparation of cold aqueous solutions of the F-127 solution, to which silver salts and other medicaments are then added, is described. By raising the temperature, these fluid liquids are then converted to strong "ringing" gels or viscous ointments which are suitable for application to a hum wound or abraded skin area. The factors involved in altering the yield strength of the gel are presented.The toxicity data of the polymeric series is reviewed.

and SummaryA brief historical review of four series of commercially available block polymer surface‐active agents—the PLURONICR, TETRONICR, PLURADOTR, and PLURONICR R polyols—is presented. A comparison is made of the physical properties within each series, in the form of trend lines. These parameters encompass solubility, rate of solubility, wetting, foaming, defoaming, emulsification, thickening, cleansing, and toxicity. The physical property relationships which depend upon variation in the hydrophobe molecular weight and variation in the hydrophile hydrophobe balance are shown to be similar in each series of surfactants. Differences among the four series of polymers, where they exist, are seen to vary from little to significant. The many controversial articles on the micellar nature of the block polymers and their critical micelle concentrations are examined. Considerations of the important physical properties which lead to practical applications are discussed. Some of the more important newly developed potential uses of these polymeric surfactants are then described in various application areas, including the cosmetic, medical, paper, pharmaceutical, and textile industries.

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The aqueous gel forming properties of three series of block copolymer surfactants, poloxamers, poloxamines, 9 | * ,

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