Acute and chronic cutaneous wounds caused by traumas, surgical interventions and a range of chronic diseases such as, for example, diabetes mellitus or chronic venous insufficiency, are widely distributed among the population all over the world, first of all among the aged patients. The treatment of acute and chronic cutaneous wounds is a current challenge for the medicine, which is not completely solved for the present day. Medicines with regenerative activity used currently have certain disadvantages, of which can be mentioned particularly the difficulties in technology and standardization of the drugs of biological origin. A range of zinc compounds (e.g., oxide, sulfate etc.) are used for a long time for the treatment of various skin diseases. Nevertheless for the present time there are some important aspects of the biological activity of zinc coordination compounds which are still not studied in detail enough, particularly the regenerative activity. In this study we investigated the regenerative activity of zinc salicylate. Zinc salicylate was prepared by reaction of an excess of zinc carbonate with salicylic acid in ethanol. Zinc salicylate activity in vitro on metabolic, proliferative and migration state of fibroblasts was investigated in cell culture. It was shown that zinc salicylate stimulates metabolic activity, increases migration state of fibroblasts, contribute to proteins adaptation to damage. Wound healing action of zinc salicylate as an active principal of a polyethyleneglycol-based ointment was studied on the model of linear wound in rats. It was shown high regenerative activity of zinc salicylate vs a standard medicine (“Levomecol”).
Increasing evidence suggests that the exogenous electromagnetic field may be involved in many biological processes of great importance for therapeutic interventions.
It is known that variable electromagnetic fields are a non-invasive, safe and effective therapeutic tool without obvious side effects. Numerous studies have shown that variable electromagnetic fields can become an independent or additional method of treating diseases of the musculoskeletal system. However, several questions remain unresolved. Prior to their widespread clinical application, further research is needed based on well-designed, high-quality studies to standardize treatment parameters and develop an optimal protocol for healthcare decision making.
In this review, we aimed to provide up-to-date data on the mechanism of action, clinical application, and controversy regarding variable electromagnetic fields in the physiotherapy of musculoskeletal disorders.
Background. In various situations healthy people may experience breathlessness caused by high altitude, breath-holding, anxiety or panic driven by stressful events, and, very often by physical activity. However, variability in perception of dyspnea in healthy individuals is yet to be explored. The present study analyzes the variability of dyspnea perception in healthy people in the context of additional respiratory resistance.Objective — to assess the variability in perception of dyspnea in healthy individuals against a step-up increase in additional respiratory resistance, and to evaluate the relationship between dyspnea perception and physical activity levels.Methods. A cross-sectional observational exploratory study involved healthy individuals aged 19–25. The study was conducted at the Department of Pathophysiology, Ryazan State Medical University named after acad. I.P. Pavlov (Russia), in the period from November 2018 to June 2019. A total number of individuals under study comprised 42. Study participants were subjected to additional respiratory resistance, when dyspnea perception was estimated using a modified Borg scale. Then all participants were divided into three groups according to the tertiles in their perception: slight perception (Borg score < 2; n = 13), moderate perception (Borg score 2–5; n = 19) and high perception (Borg score > 5, n = 13). The study involved determination of body mass index, maximal airway pressure, pulmonary function, physical activity by means of IPAQ (International Physical Activity Questionnaire) and 6MWT (6 Minute Walking Test). Data analysis was performed using IBM SPSS Statistics 17.0 (USA).Results. The study included 42 healthy individuals. The level of dyspnea perception was determined as slight (low), moderate (medium) and high in 13, 19 and 10 participants, respectively. Perceived level of breathlessness did not significantly correlate with age, gender, body mass index, physical activity, maximum airway pressure or pulmonary function test results.Conclusion. Perceived dyspnea caused by a step-up increase in additional respiratory resistance varied significantly. The perception of dyspnea was determined as slight in 31% of participants, moderate in 45% and high in 24%. The authors did not reveal a correlation between dyspnea perception and physical activity level (via IPAQ or 6 Minute Walking Test).
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