Background: Obstructive sleep apnea (OSA) is associated with obesity, metabolic syndrome, and dyslipidemia, which may be related to decrease androgen levels found in OSA patients. Dyslipidemia may contribute to atherosclerosis leading to increasing risk of heart disease. Methods: Systematic review was conducted using PubMed and Cochrane library by utilizing different combinations of key words; sleep apnea, obstructive sleep apnea, serum lipids, dyslipidemia, cholesterol, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG). Inclusion criteria were: English articles, and studies with adult population in 2 groups of patients (patients with OSA and without OSA). A total 96 studies were reviewed for inclusion, with 25 studies pooled for analysis. Results: Sixty-four studies were pooled for analysis; since some studies have more than one dataset, there were 107 datasets with 18,116 patients pooled for meta-analysis. All studies measured serum lipids. Total cholesterol pooled standardized difference in means was 0.267 (p = 0.001). LDL cholesterol pooled standardized difference in means was 0.296 (p = 0.001). HDL cholesterol pooled standardized difference in means was -0.433 (p = 0.001). Triglyceride pooled standardized difference in means was 0.603 (p = 0.001). Meta-regression for age, BMI, and AHI showed that age has signifi cant effect for TC, LDL, and HDL. BMI had signifi cant effect for LDL and HDL, while AHI had signifi cant effect for LDL and TG. S C I E N T I F I C I N V E S T I G A T I O N SO bstructive sleep apnea (OSA) is a common disorder affecting about 4% of middle-aged males and 2% of middle-aged women in the developed world and is a significant source of morbidity and mortality. 1,2 OSA is characterized by recurrent episodes of upper airway collapses during sleep. These recurrent episodes of upper airway collapse usually are accompanied by oxyhemoglobin desaturation and terminated by brief arousals which result in marked sleep fragmentation and chronic excessive daytime sleepiness (EDS). 1,2 OSA has been increasingly linked to cardiovascular and cerebrovascular disease, and many studies have shown that OSA is associated with increased cardiovascular and cerebrovascular morbidity. 3-9 OSA is associated with obesity and metabolic syndrome. 10 Multiple studies addressing this interesting and complex issue are available where lipid profi le was measured in subjects with OSA. We performed metaanalysis (MA) and meta-regression (MR) to specifi cally detect if OSA adversely affects degree of dyslipidemia; elevation of total cholesterol (TC), low density lipoprotein cholesterol (LDL), triglyceride (TG), and reduces level of high density lipoprotein cholesterol (HDL). Effect of Obstructive Sleep Apnea Hypopnea Syndrome on METHODS Data Source and Study SelectionStudies for review were found searching the PubMed, Cochrane, and EMBASE databases from January 01, 196801, , to November 30th, 2013. Unpublished data from scientifi c meetings were not searched, since...
Patients with obstructive sleep apnea and chronic musculoskeletal pain sleep not only significantly less but also with inferior sleep quality. Their REM sleep is also less in duration and its onset is delayed. Despite low TST and SE, these patients may not exhibit sleepiness.
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Objective:Pakistan ranks among the countries with highest neonatal mortality rate. Birth related event (Asphyxia neonatorum) is one of the three most common causes of neonatal mortality worldwide. Effective resuscitation during the Golden Minute can improve the mortality and morbidity. In Pakistan, a training programme NeoLiS (Neonatal Life Support) was developed in 2008 which was based on guidelines of ILCOR. The objective of this study was to assess the improvement in knowledge of healthcare professionals attending Neonatal Life Support training workshop. Methods:It was a retrospective cross sectional study that was conducted in the Neonatology Department of the Children’s Hospital, Lahore. A total of 52 workshops were conducted in 2017-18 in which 1350 health professionals were participated including doctors, nurses and paramedics. Data of all the training workshops were analysed in the study. Knowledge was tested through true/false questionnaires. The results of pre-course test were compared with respective post-course test by entering the data in SPSS and significance in improvement of knowledge was calculated by applying paired t-test. p-value <0.05 was considered significant. Results: Mean of pre-course and post-course results of all the participants were calculated and post-course results showed significant improvement in knowledge as compared to pre-course tests. Similarly, paired t-test was performed for all the results of doctors,nurses and paramedics on individual basis. The p-value in all groups was < 0.01 which was statistically significant. Conclusion: Neonatal Life Support (NeoLiS) training course resulted in significant gain in knowledge about neonatal resuscitation by healthcare professionals when assessed Continuous...
Anhydrous ammonia is a toxic gas widely used as a fertilizer.
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