Effect of musculoskeletal pain on sleep architecture in patients with obstructive sleep apnea

Nadeem, Rashid; Bawaadam, Hasnain; Asif, Asma; Waheed, Irfan; Ghadai, Ahmed; Khan, Adnan; Hamon, Sara

doi:10.1007/s11325-013-0920-6

Cited by 18 publications

(21 citation statements)

References 26 publications

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“…Among the factors affecting pain sensitivity are quantity and quality of sleep, which are both important in maintaining homeostasis of pain-regulatory processes 21 ) . Sleep disturbances are a common problem in patients with chronic pain 23 ) , and evidence suggests that sleep loss causes hyperalgesia 24 ) . Data from patients with OSAS supports a correlation between sleepiness and pain sensitivity 25 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Most studies investigating the relationship between sleep and pain have focused on sleep disturbances in pain patients, and few studies have investigated chronic pain in OSAS patients. A recent retrospective study showed that 200 of 393 patients with OSAS had chronic musculoskeletal pain 23 ) . In this study, no significant differences were observed in age, BMI, or gender between the OSAS and OSAS-plus-pain groups; however, 96.7% of subjects in the study were male.…”

Section: Discussionmentioning

confidence: 99%

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Chronic widespread musculoskeletal pain in patients with obstructive sleep apnea syndrome and the relationship between sleep disorder and pain level, quality of life, and disability

et al. 2015

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[Purpose] The aim of this study was to ascertain the prevalence of chronic widespread musculoskeletal pain in patients with obstructive sleep apnea syndrome and to assess the relationship between sleep disorder and pain, quality of life, and disability. [Subjects and Methods] Seventy-four patients were included in the study and classified as having mild, moderate, or severe obstructive sleep apnea. Chronic widespread pain, quality of life, and disability were evaluated. [Results] Forty-one patients (55.4%) had chronic widespread pain. Female patients had a higher incidence of chronic pain, and female patients with chronic pain had higher body mass indexes, pain levels, and disability scores than did male patients. Physical component scores of female patients with chronic pain were lower than those of male patients. No correlation was observed between the degree of sleep disorder and severity of pain, pain duration, disability, or quality of life in obstructive sleep apnea patients with pain. [Conclusion] This study showed a 55.4% prevalence of chronic widespread pain in patients with obstructive sleep apnea and a greater risk of chronic pain in female than in male patients. Female patients with obstructive sleep apnea and chronic pain have higher pain and disability levels and a lower quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chronic widespread musculoskeletal pain in patients with obstructive sleep apnea syndrome and the relationship between sleep disorder and pain level, quality of life, and disability

et al. 2015

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“… 99 Chronic pain patients with sleep apnea show reduced sleep duration and poorer sleep quality than those with sleep apnea without pain. 100 A large prospective study investigating the relationship between OSA and temporomandibular disorder 101 showed that people with a history of OSA are more likely to develop chronic pain. A recent animal study suggests that sleep deprivation differentially impacts obese vs lean animals on pain sensitivity; when sleep was fragmented, pain threshold was increased in the lean but not in obese mice at one of the testing times during a day.…”

Section: Potential Mechanisms Underlying the Obesity–pain Linkmentioning

confidence: 99%

The association between chronic pain and obesity

Okifuji¹,

Hare²

2015

JPR

434

337

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Obesity and pain present serious public health concerns in our society. Evidence strongly suggests that comorbid obesity is common in chronic pain conditions, and pain complaints are common in obese individuals. In this paper, we review the association between obesity and pain in the general population as well as chronic pain patients. We also review the relationship between obesity and pain response to noxious stimulation in animals and humans. Based upon the existing research, we present several potential mechanisms that may link the two phenomena, including mechanical/structural factors, chemical mediators, depression, sleep, and lifestyle. We discuss the clinical implications of obesity and pain, focusing on the effect of weight loss, both surgical and noninvasive, on pain. The literature suggests that the two conditions are significant comorbidities, adversely impacting each other. The nature of the relationship however is not likely to be direct, but many interacting factors appear to contribute. Weight loss for obese pain patients appears to be an important aspect of overall pain rehabilitation, although more efforts are needed to determine strategies to maintain long-term benefit.

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“…Type 2 diabetes is frequently associated with OSA, with obesity as a common risk factor [ 32 ]. In persons with OSA and chronic musculoskeletal pain, Nadeem et al [ 89 ] found that the pain significantly shortened sleep time and lessened the quality of sleep. Asghari et al [ 48 ] found no association between OSA and the severity of depression and anxiety symptoms; however, Rezaeitalab et al [ 45 ] found that 53.9% of the study population experienced anxiety and 46.1% depression, and that OSA severity was associated with the frequency of anxiety.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Sleep Apnea in the Canadian Population

Spuy

Zhao

Karunanayake

et al. 2018

Canadian Respiratory Journal

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Older age, obesity, hypertension, snoring, and excessive daytime sleepiness have been associated with sleep apnea. The objective of this study was to determine the prevalence (crude and adjusted), as well as the risk factors, of sleep apnea in the adult Canadian population. Data from the 2009 Sleep Apnea Rapid Response (SARR) questionnaire were used to identify the risk factors, and all sleep-related questions in the SARR questionnaire were used. The outcome variable of interest was health professional-diagnosed sleep apnea. Covariates of interest were demographic variables, population characteristics, respiratory and cardiovascular diseases, and enabling resources. The multiple logistic regression model adjusted for the clustering effect was used to analyze the data. Sleep apnea was diagnosed in 858,913 adults (3.4% of the population), and more men (65.4%) than women (34.6%) were diagnosed with sleep apnea. Multivariable logistic regression analysis indicated that age (45 and older), loud snoring, sudden awakening with gasping/choking (rare/sometimes and once or more a week), and nodding off/falling asleep in driving in the past 12 months were significantly associated with diagnosed sleep apnea. Predictive probability demonstrated that in overweight and obese persons, ≥15 minutes of daily exercise significantly decreased the risk of diagnosed sleep apnea. The conclusion of this study is that in the Canadian population, sleep apnea is associated with older age, loud snoring, and sleeping problems. The protective effect of exercise warrants further investigation.

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Effect of musculoskeletal pain on sleep architecture in patients with obstructive sleep apnea

Abstract: Patients with obstructive sleep apnea and chronic musculoskeletal pain sleep not only significantly less but also with inferior sleep quality. Their REM sleep is also less in duration and its onset is delayed. Despite low TST and SE, these patients may not exhibit sleepiness.

Cited by 18 publications

References 26 publications

Chronic widespread musculoskeletal pain in patients with obstructive sleep apnea syndrome and the relationship between sleep disorder and pain level, quality of life, and disability

Chronic widespread musculoskeletal pain in patients with obstructive sleep apnea syndrome and the relationship between sleep disorder and pain level, quality of life, and disability

The association between chronic pain and obesity

Predictors of Sleep Apnea in the Canadian Population

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