TNF-alpha inhibition does not alter insulin resistance in IBD patients. In contrast, total cholesterol, HDL cholesterol and apo-A1 levels are significantly increased after infliximab treatment compared with baseline. The importance of these alterations needs to be clarified in future studies.

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Neural network literature for function approximation is by now sufficiently rich. In its complete form, the problem entails both parametric (i.e., weights determination) and structural learning (i.e., structure selection). The majority of works deal with parametric uncertainty assuming knowledge of the appropriate neural structure. In this paper we present an algorithmic approach to determine the structure of High Order Neural Networks (HONNs), to solve function approximation problems. The method is based on a Genetic Algorithm (GA) and is equipped with a stable update law to guarantee parametric learning. Simulation results on an illustrative example highlight the performance and give some insight of the proposed approach.

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