Changing trends in acute upper gastrointestinal bleeding in Crete, Greece

Paspatis, Gregorios A.; Konstantinidis, Konstantinos; Chalkiadakis, Ioannis; Tribonias, George; Chlouverakis, Gregorios; Roussomoustakaki, Maria

doi:10.1097/meg.0b013e32834c3a02

Cited by 10 publications

(10 citation statements)

References 5 publications

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“…However, given that a significant proportion of UGIH cases have no cause identified at endoscopy, estimation of incidence remains reliant on clinical parameters . Published estimates vary significantly, between 48 and 172 per 100 000 adults per year (all incidence figures quoted per 100 000 adults per year) . To our knowledge, no description of incidence of UGIH in Maori has been published.…”

Section: Introductionmentioning

confidence: 99%

Incidence of upper gastrointestinal haemorrhage in Maori and New Zealand European ethnic groups, 2001–2010

Irwin

Ferguson

Weilert

et al. 2014

Internal Medicine Journal

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Section: Introductionmentioning

confidence: 99%

Incidence of upper gastrointestinal haemorrhage in Maori and New Zealand European ethnic groups, 2001–2010

Irwin

Ferguson

Weilert

et al. 2014

Internal Medicine Journal

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“…In the United States, GIB accounted for more than 500,000 hospitalizations and consumed nearly US$5 billion in 2014 1 . With the increasing use of proton pump inhibitors (PPIs) and Helicobacter pylori eradication therapy, the incidence of upper GIB (UGIB) is declining 2–8 . On the other hand, epidemiological data on lower GIB (LGIB) are limited.…”

Section: Introductionmentioning

confidence: 99%

Divergent trends of hospitalizations for upper and lower gastrointestinal bleeding based on population prescriptions of aspirin, proton pump inhibitors and Helicobacter pylori eradication therapy

Guo

Zhang

et al. 2021

UEG Journal

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Background With the increasing use of medications that alter the risk of gastrointestinal bleeding (GIB), comprising aspirin, proton pump inhibitors (PPIs), and Helicobacter pylori eradication therapies, the trends of GIB are evolving. Objective The aim of this study is to determine and predict the trends of GIB and to evaluate the effects of population prescriptions of these medications on GIB incidences. Methods We retrieved patients hospitalized for GIB in all public hospitals in Hong Kong between 2009 and 2019. Monthly age‐ and sex‐standardized GIB data were fitted and predicted, based on population prescriptions of aspirin, nonsteroidal anti‐inflammatory drugs (NSAIDs), anticoagulants, other antiplatelet drugs, PPIs, and H. pylori therapies, using autoregressive integrated moving average model for time series analysis. Results The incidence of upper GIB (UGIB) showed a clear declining trend while lower GIB (LGIB) decreased slightly. Older population (>80 years) had the greatest decline in UGIB but was associated with an increase in LGIB. Prescriptions of PPIs and aspirin increased significantly with time. PPIs prescriptions were negatively associated with UGIB incidence (coefficient log(PPIs) −4.58; 95% confidence interval [CI]: −5.69, −3.47). H. pylori eradication in the previous month showed a nonsignificant trend on UGIB (coefficient −0.14; 95% CI: −0.30, 0.02). In contrast, aspirin increased the incidences of UGIB (coefficient 0.06; 95% CI: 0.04, 0.07) and LGIB (coefficient 0.04; 95% CI: 0.03, 0.05). NSAIDs, anticoagulants, and other antiplatelet drugs were not significantly associated with the trend of either UGIB or LGIB. UGIB is predicted to decline continuously but LGIB is projected to rise, particularly with increasing use of aspirin. Conclusions UGIB incidences were decreasing and had been surpassed by LGIB. Based on population prescriptions of aspirin and PPIs, divergent trends of upper and lower GIB are expected, especially in elderly.

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“…Loperfido et al reported that the annual mortality of UGIB decreased from 17.1/100,000 during the period of 1983-1985 to 8.2/100,000 during the period of 2002-2004 [4]. Paspatis et al also reported that the annual mortality of UGIB decreased from 9/100,000 during the period of 1998-1999 to 6.3/100,000 during the period of 2008-2009 [5]. However, Theocharis et al found that the overall mortality increased from 3.9% in 1995 to 6.5% in 2005, but no statistically significant difference was found between the two periods [6].…”

Section: Mortalitymentioning

confidence: 98%

“…In Italy, there were 532 patients with 587 admissions during a 2-year period from 1983 to 1985 and 513 patients with 539 admissions during a 2-year period from 2002 to 2004 [4]. In Crete, Greece, a population-based study found that the annual incidence of acute UGIB was 160/100,000 during a 1-year period from 1998 to 1999 and 95/100,000 during a 1-year period from 2008 to 2009 [5]. In Achaia, Greece, a population-based study found that the annual incidence of acute UGIB was 162.9/100,000 and 108.3/100,000 in1995 and 2005, respectively [6].…”

Section: Incidencementioning

confidence: 99%

Red Blood Cell Transfusion Strategy for Upper Gastrointestinal Bleeding

Qi¹,

Romeiro²,

Li³

2017

Transfusion Medicine and Scientific Developments

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Acute upper gastrointestinal bleeding (UGIB) is a potentially lethal and frequent digestive disease. It is mainly divided into the nonvariceal UGIB and variceal bleeding according to the source of bleeding. Red blood cell transfusion is the core therapeutic option for the management of acute UGIB. In this chapter, we reviewed the primary evidence from meta-analyses and large-scale randomized controlled trials regarding red blood cell transfusion strategy for acute UGIB.

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Changing trends in acute upper gastrointestinal bleeding in Crete, Greece

Cited by 10 publications

References 5 publications

Incidence of upper gastrointestinal haemorrhage in Maori and New Zealand European ethnic groups, 2001–2010

Incidence of upper gastrointestinal haemorrhage in Maori and New Zealand European ethnic groups, 2001–2010

Divergent trends of hospitalizations for upper and lower gastrointestinal bleeding based on population prescriptions of aspirin, proton pump inhibitors and Helicobacter pylori eradication therapy

Red Blood Cell Transfusion Strategy for Upper Gastrointestinal Bleeding

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