ABSTRAKPenelitian ini bertujuan untuk mengetahui karakteristik demografis dan klinik serta profil penggunaan obat pada pasien hipertensi esensial di instalasi rawat jalan RSUD I Lagaligo Kabupaten Luwu Timur periode Januari-Desember 2014. Metode penelitian yang dilakukan adalah Deskriptif yang dikerjakan secara retrospektif dengan mengumpulkan data sekunder dari rekam medik pasien Hipertensi esensial yang menjalani rawat jalan di RSUD I Laga Ligo Kabupaten Luwu Timur periode Januari-Desember 2014. Jumlah sampel dalam penelitian adalah 145 pasien. Karakteristik demografi perempuan yaitu 87 pasien (60%), rentang usia 41-60 tahun (55,86%), Hipertensi grade 1 (73,78%), golongan obat yang paling banyak digunakan adalah antagonis kalsium (45,45%), jenis obat Amlodipin (44,27%), bentuk sediaan tablet 100%, aturan pakai 1 sampai 2 kali sehari, terapi tunggal yaitu Amlodipin (63,08%), kombinasi 2 antihipertensi yaitu Amlodipin-Hidroklorotiazid (38,61%), kombinasi 3 antihipertensi yaitu Amlodipin-Hidroklorotiazid-Captopril (69,57%). Hasil penelitian yang diperoleh telah sesuai dengan alogaritma pengobatan hipertensi menurut JNC 7.Kata kunci: Profil penggunaan obat, Hipertensi, Antihipertensi ABSTRACTThis study aimed to determine the demographic and clinical characteristics and profile of drug use in patients with essential hypertension at outpatient installations I Lagaligo General Hospital East Luwu Regency period January-December 2014. The research method is descriptive done retrospectively by collecting secondary data from medical records essential hypertension patients undergoing outpatient treatment at General Hospital I Lagaligo East Luwu Regency period January-December 2014. The number of samples in the study were 145 patients. The dominant demographic characteristics of women that 87 patients (60%), age range 41-60 years (55.86%), hypertension grade 1 (73.78%), a class of drugs most widely used is a calcium antagonist (45.45%), the type of drug amlodipine (44.27%), 100% tablet dosage forms, rules of use 1 to 2 times a day, namely amlodipine monotherapy (63.08%), the combination of two antihypertensive amlodipinehydrochlorothiazide (38.61%), the combination of three antihypertensive amlodipine-hydrochlorothiazideCaptopril (69.57%). The results obtained in accordance with an algorithm treatment of hypertension according to Joint National Committee (JNC 7).
One of the chronic complications of diabetes mellitus is a disorder of macrovascular as hypertension so that in it’s medicinal treatment required therapy with multiple drugs all at once that can lead to drug interactions. Drug interactions can result in increased toxicity and decrease the effectiveness of drugs that interact. This study aims to determine the prescription profile of DM patients with hypertension include the number of drugs prescribed, dosage forms, classes and types of drugs and the incidence of drug interactions theoretically, based on the mechanism drug interactions in outpatient installations of RSUD Undata Palu 2014. This design research is a non-experimental study with descriptive. Retrieval of patient data performed prospectively during the period from March to June 2014. Subjects who fill the inclusion criteria is adult patients that attain age of 18-60 years and diagnosed diabetes mellitus with hypertension are interview to obtain primary data while the secondary data such as medical records and prescriptions. Retrieved 61 sample. Based on dosage forms prescribe profile that most often given to the DM patients with hypertension was tablets (94.5%). Class of diabetes drugs most widely used is a sulfonylurea (21.1%) and hypertension drug classes beta blocker (12.2%). Types of diabetic drugs most widely used was glimepiride (14.2%) and hypertension was bisoprolol (9.2%). The percentage result of drug interactions theoretically was 85.2% (52 patients), drug interactions type that the most occured was pharmacodynamic interactions 72.7%. Diabetes melitus Patients with hypertension in outpatient installations of RSUD Undata Palu 2014 were most potentially subjected to drug interactions
Corona virus infection (COVID-19) is still an unsolved problem in Indonesia until this year. Apart from Java, other islands, including Sulawesi, were also badly affected. The very high mortality rate in Central Sulawesi (3.36%) poses a challenge for health workers; therefore, they should be well informed and with up-to-date information about correct therapeutic decisions. One of the most common comorbidities that often occurs with the severity and mortality of COVID-19 is hypertension. This study aims to determine the clinical characteristics and severity profile and their relationship with the mortality rate of COVID-19 patients with hypertension in Palu, Central Sulawesi. A total of 185 data on COVID-19 patients undergoing treatment at the Palu City Hospital during 2021 and meeting the criteria were recruited as research samples. Patients were divided into two categories, hypertensive (43%) and non-hypertensive (57%). The results showed that the age group, comorbid diabetes mellitus, cardiovascular, blood pressure, and blood glucose levels showed a significant relationship between the two groups (p < 0.05). The median length of stay was 12 days, with conditions leading to discharge (83%) and death (17%); patients who died were hospitalized in moderate and severe clinical conditions. Age group, liver function, and kidney function were positively correlated with severity and mortality. However, hypertension did not show a significant relationship with the severity and mortality of COVID-19 patients.
Skin diseases, one type of diseases that is still very dominant occuring and becoming one public health problem in Indonesia, are caused by bacteria, viruses, fungi, parasite infestations or allergic reactions. They can be treated with various ways including topical, systemic and or intralesional routes. This study aimed to determine the drug use profile of patients with skin disease at Dermatology and Venereology Polyclinic in Anutapura General Hospital Palu using prospective method and data were descriptively presented. The results showed that from 98 patients, there was 53.06% male; 55.10% aged 41-65 years; and 27.55% housewifes and it was found that 100% of them had clinical manifestation of rash in which the most diagnosis of skin disease was Psoriasis vulgaris as much as 13.26%. Patients receiving 4-6 amount of drug variation were 68.37% that based on total frequency of the type of drugs used (381), the most class of therapy was topical corticosteroid anti-inflammatory drugs (23.10%), such as desoximetasone (18.11%); while based on frequency of the drug dosage forms (213), tablet was the most dominant one (43.19%). This results were in accordance with the Standards of Medical Care of Anutapura General Hospital Palu
Antidotes drug is indicated in intoxication or poisoning patients, in addition to the antidote drugs, it can also be used as an appropriate therapeutic indication of his own medicine. The high increasing number of the antidote drug used every year in inpatient instalation Undata hospital, for exmple atropine, N-acetylcysteine and pyridoxine (vitamin B6). Therefore, this study aims to determine the percentage of drug use of antidote category indicated as an antidote therapy in Undata hospitals Central Sulawesi Province period 2016-2018. This is a descriptive study with retrospective approach and using purposive sampling techniques.The results showed that the sample size was 75 patients, with the percentage of drug use as antidotes category in Undata Hospital Central Sulawesi province period 2016-2018, namely pyridoxine (vitamin B6) of 49.33%, N-acetylcysteine drug of 42.66% and the atropine drug of 8%. The use of antidotes drug category are indicated as an antidote to the poisoning therapy drugs obtained 0%. It can be concluded that there is no antidote drug category that used as an antidote therapy on patients with drug poisoning in inpatient instalation Undata hospital Central Sulawesi Province Period 2016-2018.
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