Glioblastoma multiforme is the most common and most aggressive glial tumor of central nervous system, however it is infrequently expressed with multiple lesions that can be defi ned as multifocal or multicentric, relative to their origin, and spread capacity. This presentation makes an effort to analyze clinical peculiarities and radiographic fi ndings of a patient suffering from a glioblastoma multiforme with supra and infratentorial lesions, that appeared synchronic and metachronically. In this case, drew our attention that important tumor masses at pons and midbrain did not compromise cranial nerves. Also, it was signifi cant the visualization at corpus callosum of glioma´s selective spreading through connection fi bers. It is concluded that both clinical and radiographic manifestations from this patient are exceptional, because of the absence of expected signology from the multiple infra and supratentorial lesions, and the visualization of the way of spreading.
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