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This chapter explores how higher education institutions (HEIs) that use active learning methodologies and promote co-creative and innovative environments can contribute significantly to regional development. The authors carried out a bibliometric analysis, considering the works published in journals indexed in the Scopus database for this purpose. The study aims to measure the scientific production of active teaching and learning methodologies, such as co-creation and innovation, and their contribution to regional development. The main results denounce that there is still a long way to go in exploring and emphasizing the links between HEIs, active learning, co-creation, innovation, and regional development. This path needs the involvement of the surrounding society, and private and public organizations, to be meaningful. HEIs urgently need to promote a shift in thinking about their educational practices. In today's world, complex challenges pose a real challenge to the future of higher education, and graduates who can meet these challenges represent added value to the higher education system.

This paper presents an experimental methodology of procedural content generation (PCG) for natural environments with a focus on game design and visualization. This approach allows us to define a set of instructions to shape the content generation to meet the requirements of game design and level design teams. For the validation process, we have discussed and analyzed a playtesting session.

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Interdisciplinarity promotes competencies like asking meaningful questions about a complex problem, examine, and synthesize multiple sources of information, methods, and perspectives, in order to integrate knowledge and ways of thinking across two or more established disciplines to produce cognitive advancement. The Interdisciplinary Week of Game Design challenges the students to demonstrate an interdisciplinary understanding of a complex problem that students define, organized by teams, having as its starting point a given theme. Teamwork between members of different academic years favors the sharing of knowledge among peers with different aptitudes, technical skills, and degrees of competence.