Diabetes Melitus (DM) termasuk kelompok penyakit metabolik yang ditandai dengan tingginya kadar glukosa darah. Hal ini disebabkan oleh gagalnya pankreas menghasilkan insulin atau kerja insulin yang terganggu (resistensi insulin). Tujuan penelitian untuk mengetahui aktivitas ekstrak etanol 70 % buah belimbing wuluh (Averrhoa bilimbi L) terhadap penurunan kadar glukosa darah mencit jantan (Mus musculus) galur Swiss Webster yang diinduksi aloksan. Sebanyak 30 ekor mencit jantan dibagi dalam 6 kelompok perlakuan yaitu kelompok kontrol normal, kontrol negatif (Na CMC), kontrol positif (Metformin 65 mg/kg bb), kelompok ekstrak buah belimbing wuluh 250 mg/kg bb, 500 mg/kg bb, dan 750 mg/kg bb. Data diperoleh dari pemeriksaan kadar glukosa darah menggunakan glucometer easytouch®, yaitu kadar glukosa darah puasa sebelum induksi, setelah diinduksi, dan setelah pemberian ekstrak pada masing-masing kelompok perlakuan. Hasil penelitian menunjukkan buah belimbing wuluh dengan dosis 250 mg/kg bb, 500 mg/kg bb, dan 750 mg/kg bb dapat menurunkan kadar glukosa darah mencit jantan yang diinduksi aloksan. Diduga senyawa aktif ekstrak etanol 70 % buah belimbing wuluh berperan dalam meningkatkan sensitifitas reseptor insulin dan mengakibatkan glukosa dapat diambil oleh sel untuk dimetabolisme. Berdasarkan hasil yang diperoleh dapat disimpulkan bahwa ekstrak etanol 70% buah belimbing wuluh dengan dosis 750 mg/kg bb merupakan dosis yang paling efektif terhadap penurunan kadar glukosa darah. Kata kunci: Aloksan, Averrhoa bilimbi L, kadar glukosa darah, mencit jantan (Mus musculus) ABSTRACT Diabetes Mellitus (DM) is a group of metabolic diseases characterized by high blood glucose levels. This is caused by the failure of the pancreas to produce insulin or impaired insulin action (insulin resistance). The purpose of this study was to determine the activity of 70% ethanol extract of starfruit fruit (Averrhoa bilimbi L) on the decrease in blood glucose levels in male mice (Mus musculus) strain of Webster induced by alloxan. A total of 30 male mice were divided into 6 treatment groups namely normal control group, negative control (Na CMC), positive control (Metformin 65 mg / kg bw), star fruit extract group 250 mg / kg bw, 500 mg / kg bw, and 750 mg / kg bw. Data obtained from examination of blood glucose levels using an easy touch ® glucometer, namely fasting glucosadarah levels before induction, after induction, and after administration of extracts in each treatment group. The results showed that starfruit with a dose of 250 mg / kg bw, 500 mg / kg bw, and 750 mg / kg bw can reduce blood glucose levels in male mice that are induced by alloxan. Allegedly the active compound extract of 70% ethanol starfruit fruit plays a role in increasing the sensitivity of insulin receptors and resulting in glucose can be taken up by cells to be metabolized. Based on the results obtained it can be concluded that the ethanol extract of 70% starfruit fruit with a dose of 750 mg / kg bw is the most effective dose to decrease blood glucose levels.
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