Among natural products, Brazilian propolis stands out for being considered a source for the discovery of new bioactive compounds. In the last decade, a new Brazilian propolis has been described, known as red propolis due to its reddish pigment. Since then, numerous studies revealing its major components and pharmacological activity have been carried out. Thus, this research had the aim of performing an integrative review of literature on the biological activity of Brazilian red propolis. Scientific studies in the PubMed, SciELO and LILACS databases were reviewed and analyzed using an inductive approach and indirect documentation technique. A total of 418 publications were found, and inclusion and exclusion criteria were subsequently applied, selecting a total of 18 articles. Brazilian red propolis presents numerous pharmacological properties, especially antibacterial, antifungal, antioxidant and anti-inflammatory effects. In addition, the chemical composition of this substance is different from other types of propolis already reported in literature, presenting flavonoids never before described. In this way, its chemical characteristics suggest probable therapeutic use for human consumption Keywords: Flavonoids, Apis millifera, bee. Caracterização química e ação farmacológica da própolis vermelha brasileira ResumoDentre os produtos naturais, a própolis brasileira destaca-se por ser considerada uma fonte para a descoberta de novos compostos bioativos. Na última década, foi descrita uma nova própolis brasileira, conhecida como própolis vermelha devido ao seu pigmento avermelhado. Desde então, inúmeras pesquisas revelando seus componentes majoritários e sua atividade farmacológica têm sido descritas. Dessa forma, esta pesquisa teve o objetivo de realizar uma revisão integrativa da literatura sobre a atividade biológica da própolis vermelha brasileira. Estudos científicos nos bancos de dados PubMed, SciELO e LILACS foram revisados e analisados utilizando-se uma abordagem indutiva e técnica de documentação indireta. Foram encontradas 418 publicações, sendo posteriormente aplicados critérios de inclusão e exclusão, selecionando ao todo 18 artigos. A própolis vermelha brasileira apresenta inúmeras propriedades farmacológicas, destacando-se os efeitos antibacteriano, antifúngico, antioxidante e anti-inflamatório. Além disso, a composição química desta substância é diferente dos demais tipos de própolis já relatados na literatura, apresentando flavonóides que ainda não tinham sido descritos. Dessa forma, suas características químicas sugerem provável uso terapêutico para o organismo humano.
The new coronavirus, SARS-CoV-2, which causes COVID-19 is easily transmitted from person to person. About 15% develop severe pneumonia and of these, 6% progress to severe acute respiratory syndrome (SARS) and multiple organ failure. Identify biomarkers that can predict which individuals are likely to be affected by severe disease and are at risk of death is crucial. However, the pathophysiology of the disease is not completely elucidated and the characterization of the clinical profile of people infected with SARS-CoV-2 remains unclear. Therefore, the objective of this study was to evaluate the epidemiological and laboratory profile of patients confirmed with COVID-19 and admitted to the University Hospital Lauro Wanderley, based on the correlation of laboratory tests to the evolution of the disease, determination of the most influential variables in the worsening of the disease. Data consisted of complete blood count and serum biochemical analyzes. Overall, 74 patients met all criteria of this study and were included, 40 from the Intensive Care Unit (ICU), and 34 from the Infectious Diseases Infirmary (IDP), both exclusively for patients with COVID-19. Based on these findings, patients with increased WBC count, ALT, AST, and LDH should be closely monitored as these factors predict ICU admission and mortality. Among other laboratory parameters, patients admitted to the ICU have higher levels of D-dimer compared to IDI patients. The results suggests that higher levels of D-dimer on admission is related to a worse prognosis of the disease.
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