A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested.
Background:Receptor guanylyl cyclase C regulates ion secretion and cytostasis in intestinal epithelial cells. Results: Ligand-mediated activation of guanylyl cyclase C and subsequent elevation of cGMP increase levels of p21 via PKGII and p38 MAPK. Conclusion: Guanylyl cyclase C can induce intestinal epithelial cell cytostasis and senescence via p21. Significance: Intestinal neoplasia is controlled by cGMP and p21.
The
donor–acceptor system 4 having pyrazine
scaffold as an acceptor moiety coupled to donor amino groups through
rotatable phenyl rings has been synthesized, which formed aggregates
in aqueous media, exhibited copper induced restriction to intramolecular
rotation, and served as a “not quenched” probe for the
detection of copper(II) ions. During this process, the aggregates
of derivative 4 acted as reactors and stabilizers for
the generation of CuO NPs and themselves became oxidized to form polyamine
derivative 6. Interestingly, the oxidized species 6 in combination with copper oxide nanoparticles served as
light-harvesting antennas and exhibited excellent photocatalytic efficiency
in Sonogashira coupling under mild and eco-friendly conditions (room
temperature, aqueous media, aerial conditions, and visible light irradiation).
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