Highlights d PIN1 stabilizes HP1a in complex with LaminB in a phosphorylation-dependent manner d PIN1 function maintains nuclear envelope structure under mechanical stress d PIN1 loss causes HP1a degradation, heterochromatin relaxation, transposon derepression d Loss of PIN1 nucleo-protective function contributes to Alzheimer's disease
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.