Two novel prostanoid-related marine oxylipins, tricycloclavulone (1) and clavubicyclone (2), were isolated from the Okinawan soft coral Clavularia viridis. The structures of 1, having a tricyclo[5.3.0.0(1,4)]decane ring system, and 2, having a bicyclo[3.2.1]octane ring system, were elucidated on the basis of spectroscopic analysis. Clavubicyclone showed a moderate growth inhibition activity against tumor cells in vitro.
A new bisabolane-type sesquiterpenoid, (E )-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.
Terpenes Terpenes U 0200 New Biologically Active Marine Sesquiterpenoid and Steroid from the Okinawan Sponge of the Genus Axinyssa. -(IWASHIMA, M.; TERADA, I.; IGUCHI*, K.; YAMORI, T.; Chem. Pharm. Bull. 50 (2002) 9, 1286-1289; Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., Hachioji, Tokyo 192-03, Japan; Eng.) -M. Paetzel 07-129
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