Tricycloclavulone (I) and Clavubicyclone (II), Novel Prostanoid‐Related Marine Oxylipins, Isolated from the Okinawan Soft Coral Clavularia viridis.

Iwashima, Makoto; Terada, Ikuo; Okamoto, Katsumi; Iguchi, Kazuo

doi:10.1002/chin.200251219

Cited by 1 publication

(2 citation statements)

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“…The first chemical study of the soft coral Lemnalia flava, collected off Mombasa, Kenya, has yielded lemnaflavoside and three monoacetate derivatives [55]. Clavubicyclone from Clavularia viridis exhibited mild cytotoxicity towards MCF-7 and OVCAR-3 tumour cell-lines [48]. The Okinawan soft coral Clavularia koellikeri resulted in the isolation of two new cembrane diterpenoids (1 and 2) and one new dollabelane diterpenoid, 3.…”

Section: Phyla: Cnidariansmentioning

confidence: 99%

“…Hyrtios erecta collected from the Egyptian Red Sea has been found to contain salmahyrtisol A and B and sesterstatins, all of which have shown significant cytotoxicity in human cancer cell-lines [47]. A peroxy steroid, from an Okinawan species of the genus Axinyssa, has been found to inhibit the growth of several human cancer cell-lines [48]. Three oxygenated sterols have been obtained from a collection of Polymastia tenax.…”

Section: Phyla: Spongementioning

confidence: 99%

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Anticancer Drugs Discovery and Development from Marine Organisms

Chakraborty¹,

Hsu²,

Wen³

et al. 2009

CTMC

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The chemical and biological diversity of the different marine evolutionary group is endless and therefore, this is an amazing resource for the discovery of new anticancer drugs. Comprising 34 of the 36 Phyla of life, marine ecosystems are indeed our last genetic diversity and biotechnological boundary; terrestrial systems possess only 17 Phyla. Sponges, coelenterates and microorganisms are the foremost resources of therapeutic compounds. Algae, echinoderms, tunicates, mollusks, bryozoans are also the sources of anticancer drugs from marine resources. We highlight the past and current status of marine anticancer pharmacology using different marine groups.

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Section: Phyla: Cnidariansmentioning

confidence: 99%

Section: Phyla: Spongementioning

confidence: 99%