NGS typing reveals 2 novel alleles amongst 206 class I and class II alleles.

Introduction. The epidemiology of multiple myeloma (MM) in Russia is poorly understood. Available data are limited. The aim of this study was to analyze the basic epidemiological parameters of MM in the Kirov region based on own regional population register data. Materials and methods. Five hundred and sixty-seven patients with newly diagnosed MM between 1994 and 2016 were included. The median age was 64 years (range, 29-90). The age-standardized incidence of MM in Kirov region was 1.8 cases per 100.000/year. results. During research period (23 years) we have the positive trend of the incidence and prevalence of MM and negative tendency of mortality every year. Our prognosis of the intensive incidence in Kirov region is 2.2-2.3 cases per 100.

Two new alleles were identified during routine next generation sequencing.

Three novel alleles were identified during routine next generation sequencing.

Two novel alleles, HLA‐B*18:200 and HLA‐C*04:435, are characterized.