Characterization of two new HLA alleles: HLA‐A*02:982 and HLA‐C*04:441

Abstract

Two new alleles were identified during routine next generation sequencing.

The novel HLA‐C*04:441:01:02 allele was identified in three unrelated bone marrow donors

“…The novel C*04:441:01:02 is first described in three unrelated individuals of Tartar origin unlike the most closely related allele the C*04:441:01:01 which was described of Russian origin 2 . The HLA typing of the first donor was HLA‐A*24:02:01 , 31:01:02 ; B*35:08:01 , 51:01:01 ; C*04:441:01:02 , 15:02:01 ; DRB1*07:01:01 , 15:01:01 ; DQB1*03:03:02 , 06:02:01 .…”

“…The novel allele has a three nucleotide changes when compared with the most closely related allele C*04:441:01:01 , in intron 6 at nucleotide 2578 where G > A, at nucleotide 2583 where G > C and at nucleotide 2590 where A > C (Figure 1). 1,2 Nucleotide numbering was obtained by alignment to the reference sequence provided by the IPD‐IMGT/HLA Database 1 …”