Modeling processes start from the lateral and apical walls of the alveolus, leading to the closure of the socket with newly formed bone within a month from extraction. Remodeling processes will follow the previous stages, resulting in trabecular and bone marrow formation and in a corticalization of the socket access.
Although the search for the ideal bone substitute has been the focus of a large
number of studies, autogenous bone is still the gold standard for the filling of
defects caused by pathologies and traumas, and mainly, for alveolar ridge
reconstruction, allowing the titanium implants installation.ObjectivesThe aim of this study was to evaluate the dynamics of autogenous bone graft
incorporation process to surgically created defects in rat calvaria, using
epifluorescence microscopy.Material and methodsFive adult male rats weighing 200-300 g were used. The animals received two
5-mm-diameter bone defects bilaterally in each parietal bone with a trephine bur
under general anesthesia. Two groups of defects were formed: a control group
(n=5), in which the defects were filled with blood clot, and a graft group (n=5),
in which the defects were filled with autogenous bone block, removed from the
contralateral defect. The fluorochromes calcein and alizarin were applied at the
7th and 30th postoperative days, respectively. The animals were killed at 35
days.ResultsThe mineralization process was more intense in the graft group (32.09%) and
occurred mainly between 7 and 30 days, the period labeled by calcein (24.66%).ConclusionsThe fluorochromes showed to be appropriate to label mineralization areas. The
interfacial areas between fluorochrome labels are important sources of information
about the bone regeneration dynamics.
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