Pada penelitian ini telah dilakukan uji efek analgesik dari bahan alam kombinasi Ekstrak Tapak Liman (Elephantopus scaber L) dan Rumput Mutiara (Hedyotis corymbosa L) dimana sebagai hewan coba digunakan mencit putih jantan (Mus Muscullus) yang diinduksi dengan pemberian stimulus elektrik pada bagian telapak kaki mencit. Mencit putih jantan sebagai hewan uji dibagi menjadi 4 kelompok : kelompok uji I diberi larutan kombinasi tapak liman dan rumput mutiara konsentrasi 0,13% b/v dengan dosis 52 mg/kg BB, kelompok uji II konsentrasi 0,39% b/v dengan dosis 156 mg/kg BB, kelompok pembanding diberi larutan asetosal dengan dosis 80mg/kg BB, dan kelompok kontrol diberi aquadem dengan volume pemberian 20 ml/kg BB per oral. Parameter yang diamati berupa lamanya waktu (detik) respon tangisan atau jeritan dari mencit putih jantan selama dialiri arus 15 volt setiap 10 menit sebagai respon nyeri akibat stimulus nyeri yang diberikan oleh alat Pododolorimetri. Berdasarkan analisis data secara statistik disimpulkan larutan ekstrak kombinasi Tapak Liman dan Rumput Mutiara yang diberikan pada mencit (Mus Muscullus) dengan dosis 52 mg/kg BB dan 156 mg/kg BB memiliki efek analgesik. Pada larutan kombinasi Ekstrak Herba Tapak Liman dan Rumput Mutiara yang diberikan dengan dosis 156 mg/kg BB memiliki aktivitas yang sebanding dengan Asetosal yang diberikan dengan dosis 80 mg/kg BB.
Introduction: Coronary heart disease (CHD) is a disorder of heart function due to a lack of blood in the heart muscle due to narrowing of the coronary arteries. Antiplatelet in patients with CHD is a therapy that must be obtained by patients throughout their lives to prevent recurrent attacks and deaths from CHD. In the Province of Bali, especially in Denpasar, there is a lack of information about the type of side effects that occur on antiplatelet medication, so it is necessary to do a related study. Objective: The aim of this study is to identify the type of side effects that occur on antiplatelet medication in patients with CHD. Methods: A cross-sectional study involving 97 patients was done by observed the CHD patients treated with antiplatelet medication. Side effects were evaluate using Naranjo Algorithm. Patients were divided into three groups, including a low dose aspirin user group, clopidogrel user group, and aspirin-clopidogrel combination user group. Results: Antiplatelet side effects that occur in patients include headache (2.06%), diarrhea (1.03%), cyanosis (1.03%), gastrointestinal bleeding (8.25%), heartburn (11.34%), and nausea (6.19%). These side effects only occurred in 31.96% of the total subjects. The incidence of aspirin side effects was significantly greater than clopidogrel as well as aspirin-clopidogrel in combination (p <0.05). Conclusion: Patients with CHD who use antiplatelet agents in the long term to be more aware of the potential side effects that will occur, especially heartburn in chronic low-dose aspirin users. Keywords: Coronary Heart Disease, Side Effects, Antiplatelet, Aspirin, Clopidogrel
Background: Tuberculosis (TB) is an infectious disease and is amongst the top ten leading causes of death from a single infectious agent. Non-adherence of TB patients to treatment often results in treatment drop out, causing more and more TB patients and antibiotic resistance. It is necessary to continuously provide knowledge through medical education so that patients undergo therapy regularly. Objective: This study aims to determine the effect of e-booklet education on the treatment behaviour of TB patients at the Denpasar City Health Centre. Method: This research is a quasi-experimental type of research with a one-group pre-test-post-test design method. This research used a research instrument in the form of a valid questionnaire with an R-value > R-table and Cronbach's alpha value > 0.6. E-booklet as a digital education has been compiled through focus group discussions with experts (doctors and pharmacists totalling five people). The sample in this study was 30 TB patients in four primary health centres in the city of Denpasar, which were selected by the purposive sampling method. Results: This study's results using the t-test showed a p-value = 0.0001, meaning there is a significant difference in knowledge before and after education. Before education (pre-test), the research subjects had an average score of 3.07. However, 14 days after education (post-test), the average score was 3.37. Conclusion: This study concludes that the provision of e-booklet education can increase TB knowledge in TB patients at the Denpasar City health centre.
Abstract Antibiotic resistance is closely related to the inappropriate use of antibiotics, namely the indication, dose, frequency, and duration of use. Permenkes No. 5 of 2014 states that acute pharyngitis is given antibiotic therapy if it meets the diagnostic criteria using the center criteria, but this criterion is difficult to apply because doctors take longer to diagnose. Previous research at the Klungkung I Primary Health Center used diagnosis utilizing a swab test. It was found that 100% of bacterial pharyngitis patients were negative. The strategy of delaying antibiotics for 3 days can prevent antibiotic resistance, but in therapy, without antibiotics, it is important to increase the effectiveness of therapy, it is deemed necessary by the researchers to conduct a study to analyze the factors that affect the recovery of patients with acute pharyngitis, which are mainly caused by viruses. Analyzing the factors that affect the recovery of viral pharyngitis patients. The design of the cross-sectional study was through observation of the medical record data of patients who came to the Klungkung Primary Health Center I for 3 months and got diagnostic facilities using the swab test. Patients who got a negative swab test were analyzed for the factors that influenced their recovery. Anti-inflammatory variables, rest, and paracetamol significantly affected the recovery of acute pharyngitis patients (p <0.05), and the importance index in CART analysis found that paracetamol was the most influential, followed by rest, administration of vitamins, and anti-inflammatory. Antibiotics, anti-allergies, and cough medicines do not affect the recovery of patients with acute pharyngitis viral. Paracetamol has the most effect on patient recovery, followed by rest and administration of vitamins, anti-inflammatory has very little effect on the recovery in patients of acute pharyngitis viral. Keywords: acute pharyngitis, cure, CART.
Background: Pharmacists have an important role in implementing drug reconciliation. The implementation of drug reconciliation allows the process of identifying drug administration errors due to information gaps, which we can avoid by optimizing information as early as possible at every shift in the process of providing health services through the reconciliation process. This process is crucial, especially for groups of patients with chronic diseases who have a high risk of changing health care delivery settings. Failure to identify results in errors in administering drugs that lead to worsening clinical conditions, resulting in increased service needs and health costs. Objective: Provides information about the tendency of pharmacists who work at the UPTD Bali Mandara General Hospital to reduce drug use errors through the drug reconciliation program. Methods: Thematic analysis of structured interview results. Results: Almost all participants (6 out of 8 pharmacists) tend to be willing to be involved in the drug reconciliation process. There are three main themes of consideration that underlie the tendency of pharmacists to be willing to be involved in the drug reconciliation process, namely, related to understanding the definition, purpose, and consistency of the implementation of reconciliation. In controlling the incidence of medication errors, the biggest preventable errors through medication reconciliation are drug duplication and drug discrepancy. Conclusion: The tendency for pharmacists to be involved is good, and the tendency to control the risk of medication errors is still lacking in terms of communication and consistency in filling out by all officers. Keywords: Pharmacist’s role, drug reconciliation, risk of medication errors
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