We report a novel microdevice to tune the curvature of cell-adhering surface by controlling air-pressure and micro-slit. Human aortic smooth muscle cells were cultured on demi-cylindrical concaves formed on the microdevice and their shape-adapting behaviour could be tracked when the groove direction was changed to the orthogonal direction. This microdevice demonstrated live observation of cells responding to dynamic change of anisotropic curvature of the adhering surface and could serve as a new platform to pursue the mechanobiology on curved surface.
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