Neuromodulation has wide ranging potential applications in replacing impaired neural function (prosthetics), as a novel form of medical treatment (therapy), and as a tool for investigating neurons and neural function (research). Voltage and current controlled electrical neural stimulation (ENS) are methods that have already been widely applied in both neuroscience and clinical practice for neuroprosthetics. However, there are numerous alternative methods of stimulating or inhibiting neurons. This paper reviews the state-of-the-art in ENS as well as alternative neuromodulation techniques—presenting the operational concepts, technical implementation and limitations—in order to inform system design choices.

The non-invasive estimation of blood oxygen saturation (SpO2) by pulse oximetry is of vital importance clinically, from the detection of sleep apnea to the recent ambulatory monitoring of hypoxemia in the delayed post-infective phase of COVID-19. In this proof of concept study, we set out to establish the feasibility of SpO2 measurement from the ear canal as a convenient site for long term monitoring, and perform a comprehensive comparison with the right index finger—the conventional clinical measurement site. During resting blood oxygen saturation estimation, we found a root mean square difference of 1.47% between the two measurement sites, with a mean difference of 0.23% higher SpO2 in the right ear canal. Using breath holds, we observe the known phenomena of time delay between central circulation and peripheral circulation with a mean delay between the ear and finger of 12.4 s across all subjects. Furthermore, we document the lower photoplethysmogram amplitude from the ear canal and suggest ways to mitigate this issue. In conjunction with the well-known robustness to temperature induced vasoconstriction, this makes conclusive evidence for in-ear SpO2 monitoring being both convenient and superior to conventional finger measurement for continuous non-intrusive monitoring in both clinical and everyday-life settings.

Recent work has shown that end-to-end (E2E) speech recognition architectures such as Listen Attend and Spell (LAS) can achieve state-of-the-art quality results in LVCSR tasks. One benefit of this architecture is that it does not require a separately trained pronunciation model, language model, and acoustic model. However, this property also introduces a drawback: it is not possible to adjust language model contributions separately from the system as a whole. As a result, inclusion of dynamic, contextual information (such as nearby restaurants or upcoming events) into recognition requires a different approach from what has been applied in conventional systems. We introduce a technique to adapt the inference process to take advantage of contextual signals by adjusting the output likelihoods of the neural network at each step in the beam search. We apply the proposed method to a LAS E2E model and show its effectiveness in experiments on a voice search task with both artificial and real contextual information. Given optimal context, our system reduces WER from 9.2% to 3.8%. The results show that this technique is effective at incorporating context into the prediction of an E2E system.

An ability to extract detailed spirometry-like breathing waveforms from wearable sensors promises to greatly improve respiratory health monitoring. Photoplethysmography (PPG) has been researched in depth for estimation of respiration rate, given that it varies with respiration through overall intensity, pulse amplitude and pulse interval. We compare and contrast the extraction of these three respiratory modes from both the ear canal and finger and show a marked improvement in the respiratory power for respiration induced intensity variations and pulse amplitude variations when recording from the ear canal. We next employ a data driven multi-scale method, noise assisted multivariate empirical mode decomposition (NA-MEMD), which allows for simultaneous analysis of all three respiratory modes to extract detailed respiratory waveforms from in-ear PPG. For rigour, we considered in-ear PPG recordings from healthy subjects, both older and young, patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) and healthy subjects with artificially obstructed breathing. Specific in-ear PPG waveform changes are observed for COPD, such as a decreased inspiratory duty cycle and an increased inspiratory magnitude, when compared with expiratory magnitude. These differences are used to classify COPD from healthy and IPF waveforms with a sensitivity of 87% and an overall accuracy of 92%. Our findings indicate the promise of in-ear PPG for COPD screening and unobtrusive respiratory monitoring in ambulatory scenarios and in consumer wearables.

Modern microtechnology is enabling the channel count of neural recording integrated circuits to scale exponentially. However, the raw data bandwidth of these systems is increasing proportionately, presenting major challenges in terms of power consumption and data transmission (especially for wireless systems). This paper presents a system that exploits the sparse nature of neural signals to address these challenges and provides a reconfigurable low-bandwidth event-driven output. Specifically, we present a novel 64-channel low-noise (2.1 V), low-power (23  W per analogue channel) neural recording system-on-chip (SoC). This features individually configurable channels, 10-bit analogue-to-digital conversion, digital filtering, spike detection, and an event-driven output. Each channel's gain, bandwidth, and sampling rate settings can be independently configured to extract local field potentials at a low data-rate and/or action potentials (APs) at a higher data rate. The sampled data are streamed through an SRAM buffer that supports additional on-chip processing such as digital filtering and spike detection. Real-time spike detection can achieve 2 orders of magnitude data reduction, by using a dual polarity simple threshold to enable an event driven output for neural spikes (16-sample window). The SoC additionally features a latency-encoded asynchronous output that is critical if used as part of a closed-loop system. This has been specifically developed to complement a separate on-node spike sorting coprocessor to provide a real-time (low latency) output. The system has been implemented in a commercially available 0.35-m CMOS technology occupying a silicon area of 19.1 mm (0.3 mm gross per channel), demonstrating a low-power and efficient architecture that could be further optimized by aggressive technology and supply voltage scaling.