Transparent high lead and tin-opacijied lead-alkali glazes have been extensively used throughout Europe and the Near East from theirjrst appearance in the Roman era and the tenth-to eleventh-century Islamic world, respectively, up until the present day. Using, to a large extent, information which is widely scattered through a diverse range of literature, the methods employed in the production of these two glaze types arejrst outlined and their merits are then compared with those of alkali glazes in terms of ease of preparation of the glaze mixture, ease of application of the glaze, ease ofjring, cost of production, glaze-body j t and visual appearance. The principal advantages of transparent high lead glazes as compared to alkali glazes are shown to be ease ofpreparation and application of the glaze suspension, low susceptibility to glaze 'crazing' and 'crawling' and high optical brilliance. Factors that influence the choice of tin-opacijied lead-alkali glazes include ease of production of tin oxide by melting tin and lead metals together; a reduced risk of reduction of lead oxide to lead metal and consequent blackening of the glaze; and, again, low susceptibility to 'crazing' and 'crawling'. Limits of current knowledge regarding these two glaze types and requirements for future research are outlined.

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87Sr/ 86 Sr ratios have been determined for glasses from four production sites, dated to between the sixth and the 11th centuries, in the Eastern Mediterranean region. On the basis of elemental analyses, the glasses at each location are believed to have been melted from different raw materials. Two glass groups, from Bet Eli'ezer and Bet She'an, in Israel, are believed to have been based upon mixtures of Levantine coastal sands and natron, and have 87 Sr/ 86 Sr ratios close to 0.7090, plus high elemental strontium, confirming a high concentration of modern marine shell ( 87 Sr/ 86 Sr ~ 0.7092) in the raw materials. The isotopic compositions of these two groups of glasses differ slightly, however, probably reflecting a varying ratio of limestone to shell because the sands that were utilized were from different coastal locations. Natron-based glasses from a workshop at Tel el Ashmunein, Middle Egypt, have 87 Sr/ 86 Sr values of 0.70794-0.70798, and low elemental strontium, consistent with the use of limestone or limestone-rich sand in the batch. High-magnesia glasses based on plant ash, from Banias, Israel, have 87 Sr/ 86 , probably reflecting the isotopic composition of the soils that were parental to the plants that were ashed to make the glass. Strontium and its isotopes offer an approach to identifying both the raw materials and the origins of ancient glasses, and are a potentially powerful tool in their interpretation.

Nineteen glasses from Maroni Petrera, Cyprus, dating to the sixth-seventh centuries AD, have been analysed by energy-dispersive X-ray analysis in the scanning electron microscope for major and minor elements. A subset of 15 glasses was also analysed for trace elements, using inductively coupled plasma mass spectrometry. Two groups are identified. The majority is made of glass produced in the coastal region of Syria-Palestine. The smaller group is of high iron, manganese and titanium (HIMT) glass, a widespread type of uncertain origin at the present time. The glasses appear to have undergone relatively minor mixing and recycling, and the glass material is likely to have arrived in Cyprus in the form of raw glass chunks or relatively fresh vessel cullet.

International audienc

Writing Committee for the REMAP-CAP Investigators IMPORTANCE The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.OBJECTIVE To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19. DESIGN, SETTING, AND PARTICIPANTSThe ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and January 18, 2021, within at least 1 domain; 2011 critically ill adults were randomized to open-label interventions in the immunoglobulin domain at 129 sites in 4 countries. Follow-up ended on April 19, 2021. INTERVENTIONSThe immunoglobulin domain randomized participants to receive 2 units of high-titer, ABO-compatible convalescent plasma (total volume of 550 mL ± 150 mL) within 48 hours of randomization (n = 1084) or no convalescent plasma (n = 916). MAIN OUTCOMES AND MEASURESThe primary ordinal end point was organ support-free days (days alive and free of intensive care unit-based organ support) up to day 21 (range, −1 to 21 days; patients who died were assigned -1 day). The primary analysis was an adjusted bayesian cumulative logistic model. Superiority was defined as the posterior probability of an odds ratio (OR) greater than 1 (threshold for trial conclusion of superiority >99%). Futility was defined as the posterior probability of an OR less than 1.2 (threshold for trial conclusion of futility >95%). An OR greater than 1 represented improved survival, more organ support-free days, or both. The prespecified secondary outcomes included in-hospital survival; 28-day survival; 90-day survival; respiratory support-free days; cardiovascular support-free days; progression to invasive mechanical ventilation, extracorporeal mechanical oxygenation, or death; intensive care unit length of stay; hospital length of stay; World Health Organization ordinal scale score at day 14; venous thromboembolic events at 90 days; and serious adverse events. RESULTS Among the 2011 participants who were randomized (median age, 61 [IQR, 52 to 70] years and 645/1998 [32.3%] women), 1990 (99%) completed the trial. The convalescent plasma intervention was stopped after the prespecified criterion for futility was met. The median number of organ support-free days was 0 (IQR, -1 to 16) in the convalescent plasma group and 3 (IQR, -1 to 16) in the no convalescent plasma group. The in-hospital mortality rate was 37.3% (401/1075) for the convalescent plasma group and 38.4% (347/904) for the no convalescent plasma group and the median number of days alive and free of organ support was 14 (IQR, 3 to 18) and 14 (IQR, 7 to 18), respectively. The median-adjusted OR was 0.97 (95% credible interval, 0.83 to 1.15) and the posterior probability of futility (OR <1.2) was 99.4% for the convalescent plasma group compared with the no convalescent plasma group. The treatment effects were consistent across the primary outcome and the 11...

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Carthage played an important role in maritime exchange networks during the Roman and late antique periods. One hundred ten glass fragments dating to the third to sixth centuries CE from a secondary deposit at the Yasmina Necropolis in Carthage have been analysed by electron microprobe analysis (EPMA) to characterise the supply of glass to the city. Detailed bivariate and multivariate data analysis identified different primary glass groups and revealed evidence of extensive recycling. Roman mixed antimony and manganese glasses with MnO contents in excess of 250 ppm were clearly the product of recycling, while iron, potassium and phosphorus oxides were frequent contaminants. Primary glass sources were discriminated using TiO 2 as a proxy for heavy minerals (ilmenite/spinel), Al 2 O 3 for feldspar and SiO 2 for quartz in the glassmaking sands. It was thus possible to draw conclusions about the chronological and geographical attributions of the primary glass types. Throughout much of the period covered in this study, glassworkers in Carthage utilised glass from both Egyptian and Levantine sources. Based on their geochemical characteristics, we conclude that Roman antimony and Roman manganese glasses originated from Egypt and the Levant, respectively, and were more or less simultaneously worked at Carthage in the fourth century as attested by their mixed recycling (Roman Sb-Mn). In the later fourth and early fifth centuries, glasses from Egypt (HIMT) and the Levant (two Levantine I groups) continued to be imported to Carthage, although the Egyptian HIMT is less well represented at Yasmina than in many other late antique glass assemblages. In contrast, in the later fifth and sixth centuries, glass seems to have been almost exclusively sourced from Egypt in the form of a manganese-decolourised glass originally described and characterised by Foy and colleagues (2003). Hence, the Yasmina assemblage testifies to significant fluctuations in the supply of glass to Carthage that require further attention.