The aim of the investigation was to develop a technology of manufacturing bone implants based on a hybrid polymer construction composed of poly(3-hydroxybutyrate) and sodium alginate for guided bone regeneration using 3D printing method.Materials and Methods. Complex shaped bone implants based on poly(3-hydroxybutyrate) and sodium alginate were manufactured by the method of two-stage leaching using a mold obtained by 3D printing. The appearance, morphology and structure of the obtained scaffolds were analyzed by means of scanning electron microscopy. Biocompatibility in vivo was determined based on the histology data of scaffolds implantation as bone substitutes.Results. The study of the developed hybrid 3D scaffolds from poly(3-hydroxybutyrate) and sodium alginate showed that they perform a restrictive function providing conditions for regeneration of flat cranial bones in rats.Conclusion. The developed hybrid 3D scaffolds do not interfere with normal osteogenesis and provide beneficial conditions for regeneration.
Журнал включен в Перечень рецензируемых научных изданий ВАК ~ 71 ~ течение 1 месяца наблюдений, по-видимому, благодаря введенным в конструкцию МСК и биоматериалам скаффолда, способным к стимуляции роста костной ткани. Таким образом, разработанная тканеинженерная конструкция обладает остеогенными свойствами, потенциируя регенерацию критических костных дефектов свода черепа крыс. Ключевые слова: костные имплантаты, поли-3-оксибутират, гидроксиапатит, альгинат натрия, мезенхимальные стволовые клетки, регенерация костной ткани. Thus, the developed tissue-engineered construct possesses osteogenic properties, potentiating the regeneration of critical bone defects of the cranium of rat skull.
This article discusses the modern approaches of bone tissue engineering in oral and maxillofacial surgery for repair of bone integrity. Describes the new biomaterials in bone tissue engineering, complex scaffolds containing MSC for bone repair of large and critical bone defects, the criteria for selecting biomaterial scaffolds, as well as their positive and negative properties.
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