Introduction: Infectious keratitis is one of the main causes of visual impairment. The incidence of acanthamoeba keratitis is relatively rare, while the prevalence is around 1 to 9 cases per 100.000. One of the factors supporting the occurrence of acanthamoeba keratitis is the increasing use of contact lenses around the world. Content: When there is microtrauma to the cornea, it can cause the expression of the mannose on the surface. With the emergence of mannose in the form of glycoproteins, it will be a requirement for the attachment of Acanthamoeba spp. Conclusion: Keratitis Acanthamoeba is an infectious disease of the cornea due to the use of contact lenses that are too long exposed to water which causes the entry of Acanthamoeba. This disease has a good prognosis with immediate drug administration within the first 3 weeks after the onset of symptoms.
Penyakit neoplasma myeloid merupakan suatu keadaan dimana sel myeloid dapat mengalami proliferasi klonal secara berlebihan. Salah satu klasifikasi dari penyakit tersebut adalah trombositosis esensial. Tombositosis Esensial (TE) adalah penyakit mieloproliferatif dengan ciri proliferasi berlebih pada megakariosit sehingga jumlah trombosit di dalam darah melebihi batas normal. TE dapat timbul akibat adanya mutasi dari beberapa gen yaitu gen JAK2, CALR atau MPL. Diagnosis penyakit TE ditegakkan berdasarkan hasil anamnesis, pemeriksaan fisik dan pemeriksaan penunjang berupa pemeriksaan laboratorium. Penyakit TE dapat ditangani dengan beberapa terapi diantaranya mielosupresi, antiplatelet, platelet-pheresis/thrombocytopheresis, dan inhibitor JAK. Ditinjau dari perjalanan penyakitnya, TE biasanya bersifat stabil selama 10-20 tahun atau lebih. Setelah bertahun-tahun penyakit ini dapat bertransformasi menjadi myelofibrosis maupun penyakit berbahaya lainnya jika tidak ditangani dengan baik.
Indonesia is ranked seventh out of countries that contributed to the highest number of DM in the world in 2019 and estimate that in 2045 it could reach 16.6 million cases. West Nusa Tenggara Province is one of the provinces with a fairly high DM rate reaching 21,308 with various complications due to uncontrolled blood sugar levels. High blood sugar levels in DM patients are caused by several uncontrolled factors in DM patients. This study aims to determine the factors associated with uncontrolled blood sugar levels in type 2 DM patients at the NTB Provincial Hospital. This research is a observational with a cross sectional study. The sample selection using the consecutive sampling obtained from the medical records of type 2 DM patients who were treated at the Internal Medicine Polyclinic of the NTB Provincial Hospital. The study sample size were 100 people with univariate and bivariate data analysis using the Chi-square test. The subjects in this study were dominated by patient age > 45 years (75.6%), female (51.2%), using non-insulin therapy (52.4%), and duration of type 2 diabetes < 10 years. (67.07%) with uncontrolled blood sugar status (52.4%). Bivariate analysis using the Chi-square showed that there were a statistically significant relationship between controlled blood sugar levels and patient age (p=0.021), controlled blood sugar levels with gender (p=0.008), controlled blood sugar levels and the type of therapy (p=0.008). = 0.004), and controlled blood sugar levels with duration of diabetes (0.023).
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