The effect of Perftoran (perfluorocarbon compound) on cells of the peritoneal exudate and small intestinal serosa was studied in Wistar rats with experimental peritonitis and mechanical injury. The peritoneal cavity was treated with Perftoran for preventing postoperative adhesions and the mechanisms of reparative regeneration of the mesothelium after this treatment were studied by immunohistochemical methods and scanning electron microscopy. The increase in macrophage population during the early postoperative period and its decrease at later terms prevented fibroblast activation and promoted epithelialization as early as by day 5.
Our method for evaluating the time course and intensity of antibiotics and other drugs transport in the predominant direction between the blood and lymph in humans promotes a more objective evaluation of drug circulation mechanisms, which is essential for determining the time of their repeated administration and route of administration. Calculation of the lymph/blood difference coefficient, based on parallel repeated measurements of the drug concentration in the lymph and blood, and of the lymph/blood coefficient provides complete data on the direction and time course of drug transport between the lymph and blood in the predominant direction.
Rationale. According to recent studies, purulent complications of postoperative wounds are found quite widely in surgical practice. Objective. To establish the effectiveness of an integrated approach to the treatment of purulent wounds.Methods. The most popular dressings were investigated in the treatment of purulent cavities in patients with suppurative coccygeal cyst. The studied patients in the experimental groups had various comorbidities, such as diabetes mellitus, obliterating atherosclerosis of the lower extremities. Experimental dressings include a dressing agent with antimicrobial properties (with chlorhexidine digluconate), Hydrotül, Activetex HF. Results. In the postoperative period, it is necessary to use broad-spectrum antibacterial drugs. However, in addition to the primary methods it is necessary to apply additional methods of treatment. In particular, we are talking about the use of modern dressings, as well as methods of physical impact on the wound. Among the important additional methods of treatment is physiotherapy, which has a positive effect on the vascularization of soft tissues, thereby enhancing nutrition and epithelialization of the wound. The doctor is faced with the difficult task of determining the most appropriate material for a particular patient among a wide range of dressing materials on the medical market.Conclusion. In patients with an established diagnosis of “abscess pilonidal cyst” who do not have associated diseases, it is most effective to apply a Hydrotül ointment during dressings; in patients with a concomitant diagnosis of atherosclerosis obliterans, the dressing agent with antimicrobial properties (with chlorhexidine digluconate) has the greatest effect; in patients with diabetes mellitus type II - Activetex HF.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.