Objectives: The purpose of this study is to evaluate the clinical and socio-professional functioning status after two years of evolution, on a sample of patients with first episode of psychosis, admitted in the Psychiatric Clinic in Timisoara in 2006. Methods: The initial sample was formed of 41 patients , but at the follow-up point (2008) only 28 patients were still in evidence. Diagnosis was made after ICD 10, BPRS and GAF were used as evaluation tools. Results: On the initial evaluation 32 % had a diagnosis of persistent delusional disorder, 25 % of short and transitory psychosis, 18% schizophrenia and 25% other psychosis. After 2 years of evolution 46% had a diagnosis of persistent delusional disorder, 25% schizophrenia and only 7 % had acute and transitory psychosis. In 28% of the cases the diagnosis was changed, most of the cases being the ones initially diagnosed with acute and transitory psychosis.The most stabil diagnosis was the persistent delusional disorder .In the majority of the cases we observed a lower socio-professional and family functioning. Conclusions: The results of this study sugests that the diagnosis of first episode of psychosis is partially predictive for the type of illnes, because a first episode of psychosis can evolve in different pathologies. The socio-professional and family functioning is lower in the majority of cases without a clear connection with the initial diagnosis.

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Objective: To create an image of therapeutic options available for the first episode psychsis and the way these options influence the evolution of patients. Material and methods: The present study is part of a larger follow-up study on a number of 121 patients with a diagnostic of first episode psychosis admitted in the Timisoara Psychiatric Clinic and The Day Clinic in the Timisoara Mental Health Center between 2003-2006 and prospectively monitored from the moment of their first contact with psychiatric services. Results: The average calculated duration of prodrome period and average Duration of Untreated Psychosis (DUP) are similar to the results indicated by most other studies. The results of statistical tests show that: the longest the prodrome, the worse the improvement of illness during course; a longer prodrome is correlated with a higher number of relapses during the patient's illness course and a longer Duration of Untreated Psychosis is likely to lead to an increased severity of illness. Patients' adherence to treatment is influenced both by the traits of the first psychotic episode and the way the patients perceive the side effects and the general utility of the administered medication. Conclusions: Psychiatrists have to dedicate more time and interest to establishing a therapeutic alliance with their patients with first episode psychosis; an individualized strategy is required to establish the adequate means and ways of intervention before initiating any type of therapy.

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