Clinical Evaluations on the Diagnosis of Autism

Dobre, Michaela; Stoica, I.

doi:10.5772/17912

Cited by 1 publication

(1 citation statement)

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“…We evaluated necroptosis as the probable underlying mechanism in autism and for this reason, we selected two parts of the brain (hippocampus and amygdala) that are more involved in this disease. Histological findings revealed that the number of axons in the amygdala and the size of cells in the hippocampus have been decreased in autism spectrum disorders (Dobre & Stoica, 2011). Our findings were not homogenous between males and females, but we could conclude that in the hippocampus, the expression of RIP3 was not changed significantly in 21 days of male, and female autistic pups, on the other hand, we had a significant increase in MLKL in 21 and 40 days male and female autistic pups.…”

Section: Discussionmentioning

confidence: 99%

Effect of sex differences and time of oxytocin administration on treatment of rat model of autism spectrum disorder: Focused on necroptosis markers

Shariatpanahi,

Sojoudi,

Khodagholi

et al. 2023

Intl J of Devlp Neuroscience

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Autism is a neurodevelopmental disorder. A variety of molecular and cellular abnormalities leads to behavioral deficits in autism. Nevertheless, its etiology and treatment strategy are not completely understood. Oxytocin has recently shown improvements in social functioning. This study aimed to evaluate the necroptosis pathway for the neuroprotective effects of oxytocin in the valproic acid‐induced autism spectrum disorder model. The autism spectrum disorder was induced by valproic acid on gestational day 12.5 (600 mg/kg, intraperitoneally). Offspring received intranasal oxytocin (1 μg/μL) on the 21st and 40th days after birth. The offspring behaviors were scrutinized by self‐grooming, marble‐burying, three‐chamber, and Morris water maze tests. Western blot was performed on the hippocampus and amygdala tissues to investigate the expression of RIP3 and MLKL markers. The valproic acid group demonstrated more anxiety, repetitive behaviors, and expression of RIP3 and MLKL markers, and less social interaction and spatial memory compared with the control group. Oxytocin considerably improved social interactions, preference for social novelty, and memory. The elevated expression of RIP3 and MLKL markers in valproic acid‐induced autistic rats were alleviated after treatment with oxytocin. We also highlighted the importance of age and gender in autism spectrum disorder interventions. Our findings suggested that oxytocin administration was as an effective treatment in two areas of repetitive/stereotyped behaviors, social interactions/cognitive function. Notably, early administration of oxytocin resulted in better therapeutic responses in autism‐like behaviors. The molecular tests introduce oxytocin as a potential candidate for reducing the expression of necroptosis mediators in the brain. This reinforced our hypothesis that the necroptosis pathway takes part in autism spectrum disorder.

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Section: Discussionmentioning

confidence: 99%