The larynges of 30 unmated, mature female albino mice were examined histologically and histochemically after injecting them with 19-nandrolone phenylpropionate. Permanent irreversible changes, in the form of parakeratosis and squamous metaplasia of the epithelium, and hypertrophy of the muscle fibers, were observed together with persistence of increased alkaline phosphatase enzyme intensity in the endothelium of capillaries and increased activity of nonspecific esterase in the muscles. Similar changes may be responsible for the alteration in the human female's voice after prolonged treatment with anabolic steroids.
Thirty six female rabbits half of which at four months of age while the other half aged eight months. Each group of age was divided into three subgroups of an equal number and received 0.0, 0.5, and 1.0 ppm zearalenone (F-2) in the feed of young animals and 0.0, 1.0 and 4.0 ppm in the feed of the old one for 18 days. The data showed that zearalenone administration to young rabbit diets elevated body weight gain, feed intake, water consumption, digestibility and digesta contents of dry matter and ash. Haemoglobin percent, packed cell volume, and serum calcium, phosphorus and vitamin C were also increased in response to dietary F-2. Liver dry matter, ether extract and ash contents as well as bone density, ash and silica contents were considerably elevated in the young treated animals. The opposite trend however, was seen for all studied parameters of old rabbits fed on diets supplemented with F-2. On the other hand, zearalenone application caused a noticeable histopathological changes in liver, kidneys, lungs, heart, adrenal glands, spleen and uterus. Thus, and in spite of its improving the performance of young rabbits, it would not be recommended to use F-2 as anabolic agent in rabbits diet.
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