Coronary stenosis is one of the major causes of death from heart disease. The gold standard of coronary stenosis diagnosis isestablished with angiography, however it is invasively, complicated and expensive. Serum Amyloid A (SAA) is an acute phase proteinthat appears as chronic and acute inflammatory agent that is specific to the process of stenosis development. Serum Amyloidal A testmethod is noninvasive, relatively easy and affordable. The aim of this study was to know the differences of Serum Amyloid A levelsin patients with nonstenosis and coronary stenosis in Dr. Sardjito General Hospital Yogyakarta by determination. The study is a casecontrol study. The samples were selected consecutively with typical chest pain, were divided into two (2) groups of nonstenosis andstenosis by coronary angiography test. The principal of the Serum Amyloid A test is ELISA method. Nonstenosis and coronary stenosisgroups were analyzed by mean of Serum Amyloid A level based on the angiography test. The data were analyzed with Independentt-test, odds ratio with a significancy of p <0.05 and confidence interval 95%. The samples of this study consisted of 60 patients, dividedinto nonstenosis and coronary stenosis. The analysis of Independent t tests showed significant differences between the subject SAA levelsof nonstenosis and stenosis (4.35 ug/mL vs 21.75 mg/mL, p=0.001, with an odds ratio 9.84 (CI 95% 2.38 to 40.73). Based on thisstudy, it can be conclued that the results indicate significantly higher level of Amyloid A Serum among the coronary stenosis comparedto the nonstenosis.
Heart-Fatty Acid-Binding Protein (H-FABP) is a membrane-bound protein that facilitates transport of fatty acids from the blood intothe heart. It is a low molecular weight cytoplasmic protein. Because of its small size and location, it is released rapidly into the bloodfollowing myocardial damage. The H-FABP levels rise as early as between 1−3 hours after the onset of Acute Coronary Syndrome, thepeak situation between 6−-8 hours, and returns to normal within 24 hours. The purpose of this study was to know the cut-off value ofHeart Fatty Acid Binding Protein with a sensitivity of at least 90% in patients with acute coronary syndrome in the Dr. Sardjito HospitalYogyakarta. The researchers undertook a cross sectional evaluation of 75 consecutive patients admitted with acute chest pain suggestiveof acute coronary syndrome (ACS). The H-FABP was measured by using immunoturbidimetry assay methods. The receiver operatingcharacteristic (ROC) analysis was calculated for the cut off point, sensitivity and specificity estimation. A total of 75 patients (59 in theACS group and 16 in the control group) were included in this study, and the majority of the ACS group (64 [76.2%]) were male patientswith AMI, 20 (26.7%) had an ST-elevation myocardial infarction and the rest (21 [28%]) had a non–ST-elevation myocardial infarction.The optimized cut-off obtained for h-FABP was 15 ng/mL, showing a sensitivity and specificity of the H-FABP assay for detecting ACSas 98.31 (95% CI 90 to 100) and 93.75% (95% CI 86 to 99), respectively. The areas under the receiver operator characteristic (ROC)curves to distinguish ACS from non-ACS were 0.983 (95% CI: 0.927– 0.999) for H-FABP. The optimized cut-off obtained for H-FABPwas 15 ng/mL, showing a 98.31% sensitivity and 93.75% specificity for detecting ACS in the Dr. Sardjito Hospital Yogyakarta.
Coronary stenosis is one of the major causes of death from heart disease. The gold standard of coronary stenosis diagnosis is established with angiography, however it is invasively, complicated and expensive. Serum Amyloid A (SAA) is an acute phase proteinthat appears as chronic and acute inflammatory agent that is specific to the process of stenosis development. Serum Amyloidal A test method is noninvasive, relatively easy and affordable. The aim of this study was to know the differences of Serum Amyloid A levels in patients with nonstenosis and coronary stenosis in Dr. Sardjito General Hospital Yogyakarta by determination. The study is a case control study. The samples were selected consecutively with typical chest pain, were divided into two (2) groups of nonstenosis and stenosis by coronary angiography test. The principal of the Serum Amyloid A test is ELISA method. Nonstenosis and coronary stenosis groups were analyzed by mean of Serum Amyloid A level based on the angiography test. The data were analyzed with Independent t-test, odds ratio with a significancy of p <0.05 and confidence interval 95%. The samples of this study consisted of 60 patients, divided into nonstenosis and coronary stenosis. The analysis of Independent t tests showed significant differences between the subject SAA levels of nonstenosis and stenosis (4.35 ug/mL vs 21.75 mg/mL, p=0.001, with an odds ratio 9.84 (CI 95% 2.38 to 40.73). Based on this study, it can be conclued that the results indicate significantly higher level of Amyloid A Serum among the coronary stenosis compared to the nonstenosis.
Gestational Diabetes Mellitus (GDM) is glucose intolerance during pregnancy. Adiponectin causes a decrease in glucose transporter 4 translocation, which reduces glucose uptake due to downstream insulin signal delivery and decreases non-esterified fatty acids so that triglyceride synthesis decreases in pregnancy. This study was conducted to determine the relationship between adiponectin and triglyceride levels in pregnancy, especially in a pregnant female with and without gestational diabetes mellitus. This observational cross-sectional study was conducted by measuring the levels of adiponectin and triglycerides in pregnancy, with and without gestational diabetes mellitus. Researchers proved by analyzing 75 subjects, 24-28 weeks pregnant females who were examined at the primary health center and Dr. Sardjito Hospital, Yogyakarta. Adiponectin levels have a moderate negative correlation with triglycerides in pregnant females (r= -0.420 and p=0.002), a strong negative correlation with GDM (r = -0.680 and p=0.001), and moderate negative correlation (r= -0.455, and p=0.022) with those without GDM. Based on this research can be concluded that adiponectin has a moderate negative correlation with triglycerides in pregnancy, a strong negative correlation in pregnant females with gestational diabetes mellitus, and a moderate negative correlation in those without gestational diabetes.
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