As part of an ongoing study of the influence of environmental factors on pregnancy, childbirth, and fetuses, comparisons have been made between incidences in 1969-1974 and in 1980-1982 of chromosome aberrations in liveborn children in the same area of Denmark. The incidence of chromosome aberrations in the first period was 2.6 per 1000, compared with 41. per 1000 during the latter period. However, the difference was mainly due to an increase in inversions, and this in turn was due to a difference in chromosome staining methods between the two periods. It is concluded that the Danish study and similar studies in the United States, Canada, and Scotland indicate that early detection of chromosome aberrations by chromosome examination at birth is indicated in order to be able to inform and counsel parents of children with chromosome aberrations. Chromosome examination at birth is also of importance in the diagnosis of structural inheritable chromosome aberrations and consequent family investigation and genetic counseling.
A dose of 50 microgram anti-D immunoglobulin was administered as rhesus immunoprophylaxis following induced abortion performed by suction curettage before the thirteenth week of pregnancy in 463 consecutive patients. A feto-maternal blood loss of less than 2 ml was detected in 44 women (12%). After 6 months, a follow-up of 381 patients (82%) established that none of these patients was rhesus immunized with in vitro demonstrable antibodies. It is concluded that the low dose of anti-D administered is to be recommended for rhesus immunoprophylaxis after first trimester abortion.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.