Low Dose Rhesus Immunoprophylaxis after Early Induced Abortions

Gjøde, P; Moulvad, I; Hansen, Jørgen Trier; Jørgensen, J.

doi:10.3109/00016348209156538

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…In Denmark, where 300 pg immune globulin is now given routinely after delivery, abortion or ectopic pregnancy, a program including prenatal prophylaxis could be organized approximately within the existing economic limits, provided that the resources of anti-D were distributed in a more differentiated way than they are today. The dose given after first-trimester abortions can be reduced to 50 pg without any risk of immunization (13). To further reduce the amount of immune globulin needed, prenatal prophylaxis may be restricted to primiparae (Table 111).…”

Section: Discussionmentioning

confidence: 99%

Prenatal Rh‐Immune Prophylaxis With 300 μg Immune Globulin Anti‐D In The 28th Week Of Pregnancy

Trolle

1989

Acta Obstet Gynecol Scand

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As immune globulin anti-D given in the immediate post partum period fails to prevent the development of anti-D antibodies in about 1.5-2% of women at risk, probably as a result of feto-maternal bleeding during pregnancy, 300 micrograms of immune globulin anti-D was administered to 609 Rh-negative women in the 28th gestational week. Three hundred and forty-six had Rh-positive babies, and were given additionally 200 micrograms anti-D post partum. Of these, 291 had an antibody screen test done 10 months after delivery. No anti-D antibodies were found. The test results of the study group were compared with those of a control group of 354 women who did not receive prenatal immune globulin, but otherwise the same examinations and treatment. In this group, 322 had a screen test performed 10 months post partum or in their next pregnancy, when 1.8% had anti-D antibodies. The difference in immunization incidence between the groups was significant (p less than 0.05). There was no difference between the groups regarding the number of women with fetal erythrocytes in serum after delivery, but the number of fetal erythrocytes found was significantly lower in the group receiving prenatal prophylaxis (p less than 0.001). No adverse effects were found in the infants exposed to anti-D prenatally.

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Section: Discussionmentioning

confidence: 99%