Alveolar-arterial Oxygen Tension Differences are one of the oxygenations that can increase SARS-CoV-2 virus infection. Based on this, the researchers wanted to assess the relationship between the baseline AaDO2 gradient and spirometry tests in severe COVID-19 survivors. This research is an observational analytic study with a cross-sectional design. The analysis was carried out in bivariate and multivariate tests assisted by using SPSS 26. The subjects who participated in the study were 80 people. Subjects with AaDO2 values > 39.4 mmHg 70% (n=56), median AaDO2 gradient was 60.45 (2.75 - 548.2 mmHg). The relationship between baseline AaDO2 analysis and spirometry results showed that it was associated with FVC and FEF25-75% results, respectively (PR) 18.6 (95% CI 3.978-87.401 p = <0.001) and (PR) 7.7 (95% CI 1.606-3.724 p = 0.011) and no significant with FEV1 and FEV1/FVC values. This study concludes a relationship between a high baseline AaDO2 gradient with FVC and FEF values of 25-75% in severe adult COVID-19 survivors. There was no relationship between a high baseline AaDO2 gradient and FEV1 and FEV1/FVC values.
The post-COVID-19 syndrome can affect the patients' activities. The hyperinflammatory response resulting in permanent organ system damage or prolonged inflammation is thought to cause persistent symptoms. Inflammatory and coagulation markers C-reactive protein (CRP) and d-dimer may increase in acute phase of SARS-CoV-2 infection and associated with unexpected outcome. Therefore, the researcher wanted to assess the association of baseline CRP and d-dimer levels with the six-minute walk test (6MWT) in severe COVID-19 survivors. This is a cross-sectional, observational analytic study. A total 80 participants were included in this study. The proportion of subjects with poor results of 6MWT was 71.3%. Bivariate analysis of high baseline level of CRP and d-dimer, and age 65 years old on the 6MWT showed significant results, with prevalence ratio (PR) consecutively 1.8 (95% CI1.408-2.284;p= <0.001),1.4 (95% CI1.165-1.796;p=0.018) , and 1.5 (95% CI 1.287-1.831; p= 0.008). Based on multivariate analysis, only high baseline level of CRP was significant (PR = 1.8, 95% CI 1.051-3.136; p = 0.032). The proportion of severe COVID-19 survivors with poor 6MWT was high. There is a significant association between high baseline levels of CRP with a poor 6MWT in severe COVID-19 survivors.
Pendahuluan. Pasien COVID-19 dengan diabetes melitus (DM) tipe 2 memiliki morbiditas dan mortalitas yang tinggi. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara DM tipe 2 dengan berbagai luaran pada pasien COVID-19 di Rumah Sakit Sanglah Denpasar, Bali.Metode. Sebuah penelitian observasional analitik dengan pendekatan cross-sectional dilakukan pada pasien COVID-19 dengan dan tanpa komorbid DM tipe 2. Data yang digunakan adalah data sekunder dari rekam medis pasien terkonfirmasi COVID-19 yang dirawat di RSUP Sanglah mulai tanggal 1 Agustus 2020 sampai dengan 28 Februari 2022 dengan menggunakan teknik total sampling.Hasil. Terdapat 1.056 pasien yang terlibat dalam penelitian ini. Pasien didominasi oleh kelompok laki-laki (n=571; 54,1%), dengan median usia 59 tahun. Sebagian besar pasien dikategorikan sebagai COVID-19 berat (n=641; 60,7%) dan sebanyak 275 pasien menderita DM tipe 2 (26,0%). Analisis bivariat menunjukkan hubungan yang signifikan pada DM tipe 2
BACKGROUND Anal human papillomavirus (HPV) is associated with the severity of anal cytologic abnormalities that are precancerous lesions. Knowledge of HPV type distribution in populations at risk for anal cancer is needed. This study investigated anal HPV infections and cytological abnormalities among men who have sex with men (MSM). METHODS A cross-sectional study was conducted involving 90 men aged >30 years with a history of anal sexual intercourse with men. Demographic characteristics and sexual behaviors were collected by using a self-completed questionnaire. Anal cytological results were examined, and HPV genotyping was performed by the Linear Array HPV genotyping test. Descriptive analyses of subject characteristics, prevalence, and 95% confidence intervals (CI) were performed. A chi-square test was used to determine their associations with high-risk HPV infection and cytological abnormalities. RESULTS The overall prevalence of abnormal cytology was 32% (24/75), atypical squamous cells of undetermined significance (ASCUS) 17.33 % (13/75), 14.66% (11/75) were classified as low-grade SIL (LSIL) and no participant had high-grade SIL (HSIL). Prevalence of HPV infection with normal cytology was 86.27% (44/51), ASCUS 92.30% (12/13), and LSIL 100% (11/11). The most common types of anal HPV in participants with cytological abnormalities are HPV 16, HPV 18 for high-risk HPV, and HPV 11, HPV 6 for low-risk HPV. There were no associations between the predictor variables and the abnormal cytology (p>0.05). CONCLUSION There was a high prevalence of HPV infection in MSM with abnormal anal cytology. A routine anal Pap smear program and vaccination are needed to prevent HPV infection and anal dysplasia in MSM.
Background Chronic hepatitis C virus (HCV) infection contributes to substantial morbidity and mortality among adults living with HIV. Cascades of HCV care support monitoring of program performance, but data from Asia are limited. We assessed regional HCV coinfection and cascade outcomes among adults living with HIV in care from 2010–2020. Methods Patients ≥18 years old with confirmed HIV infection on antiretroviral therapy (ART) at 11 clinical sites in Cambodia, China, India, Indonesia, South Korea, Thailand and Vietnam were included. HCV- and HIV-related treatment and laboratory data were collected from those with a positive HCV antibody (anti-HCV) test after January 2010. An HCV cascade was evaluated, including proportions positive for anti-HCV, tested for HCV RNA or HCV core antigen (HCVcAg), initiated on HCV treatment, and achieved sustained virologic response (SVR). Factors associated with screening uptake, treatment initiation, and treatment response were analyzed using Fine and Gray’s competing risk regression model. Results Of 24,421 patients, 9169 (38%) had an anti-HCV test, and 971 (11%) had a positive result. The proportion with positive anti-HCV was 12.1% in 2010–2014, 3.9% in 2015–2017, and 3.8% in 2018–2020. From 2010 to 2014, 34% with positive anti-HCV had subsequent HCV RNA or HCVcAg testing, 66% initiated HCV treatment, and 83% achieved SVR. From 2015 to 2017, 69% with positive anti-HCV had subsequent HCV RNA or HCVcAg testing, 59% initiated HCV treatment, and 88% achieved SVR. From 2018 to 2020, 80% had subsequent HCV RNA or HCVcAg testing, 61% initiated HCV treatment, and 96% achieved SVR. Having chronic HCV in later calendar years and in high-income countries were associated with increased screening, treatment initiation or achieving SVR. Older age, injecting drug use HIV exposure, lower CD4 and higher HIV RNA were associated with reduced HCV screening or treatment initiation. Conclusions Our analysis identified persistent gaps in the HCV cascade of care, highlighting the need for focused efforts to strengthen chronic HCV screening, treatment initiation, and monitoring among adult PLHIV in the Asia region.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.