Serum and lung tissue levels in fifteen patients who underwent thoracic surgery were determined by the agar‐diffusion plate method after i.m. administration of cephradine (500 mg). The mean value of the serum level 30 to 120 min after administration was 6.5 mug/ml, the mean lung tissue level was 2.6 mug/g. The lung tissue levels reached 40% of the simultaneous serum level. Four patients received cephradine for the treatment of post‐operative chest infections. This antibiotic has an important therapeutic role in cases of thoracic‐surgical infections.
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