Serum and lung tissue levels in fifteen patients who underwent thoracic surgery were determined by the agar‐diffusion plate method after i.m. administration of cephradine (500 mg). The mean value of the serum level 30 to 120 min after administration was 6.5 mug/ml, the mean lung tissue level was 2.6 mug/g. The lung tissue levels reached 40% of the simultaneous serum level. Four patients received cephradine for the treatment of post‐operative chest infections. This antibiotic has an important therapeutic role in cases of thoracic‐surgical infections.

Aelurostrongylus abstrusus is the most important respiratory parasite infecting domestic cats worldwide. Nevertheless, most records and epizootiological data come from Europe, whilst poor and fragmentary information are available for other regions, including the Americas. The present article describes the first description of cat aelurostrongylosis from Amazonia, Brazil. Eighty-one cats, 13 from a shelter and 68 admitted at the Teaching and Research Unit in Veterinary Medicine (UV) at the Federal University of Acre (UFAC), Brazil, were included in the study. For all cats, three faecal samples from consecutive defecations were examined using the Baermann’s technique. Nematode first stage larvae (L1), retrieved in 2/81 (2.5%) samples, were microscopically identified as A. abstrusus and then subjected to a molecular assay able to identify the three most important species of metastrongyloids infecting felids. This test confirmed the A. abstrusus identity in one sample, while the second scored negative. The cat with confirmed aelurostrongylosis showed radiographic changes, i.e., an interstitial pattern, compatible with the infection. The other cat, which scored positive at the Baermann’s examination, was apparently healthy at the physical examination and showed no thoracic alterations. The occurrence of A. abstrusus in domestic cats from Brazilian Amazon is herein demonstrated for the first time. Clinical, epizootiological and molecular implications are discussed.

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Forty-two patients with chronic renal insufficiency were subjected to Brulamycin therapy to combat complications such as sepsis, infection of the lower respiratory tract (bronchopneumonia) or of the urinary tract, Cimino fistula inflammation or peritonitis when the pathogenic agent was sensitive to nothing but aminoglycosides. The proper Brulamycin dose was selected under close clinical and laboratory control so as to fit the dialysed patient and his state of impaired renal function. The various forms of dialysis have been studied to determine their Brulamycin blood level diminishing effects. Familiarity with these effects is as important as with the patient's age, sex, body weight and actual state of renal function. The results confirm the experience gained by other authors that Brulamycin treatment--in curative non-toxic doses as indicated by the blood level index--is useful against severe infectious complications in anuric patients.

RESUMO:O etil-cianoacrilato (ECA) que é um éster do ácido cianoacrílico de cadeia curta tem sido usado extensivamente em síntese cutânea. O objetivo deste estudo foi avaliar a eficiência do ECA na síntese de excisões cutâneas de ratos Wistar machos. Foram utilizados 16 ratos da linhagem Wistar e divididos em dois grupos, cada um com oito animais. Os ratos foram premedicados com xilazina (3 mg/Kg IM) e cetamina (70 mg/Kg IM) e tricotomizados manualmente. Realizou-se a antissepsia com solução alcoolica a 70% e clorhexidina a 0,5%, seguido de colocação de panos de campo descartáveis. Foi efetuada uma incisão longitudinal de cinco centímetros no dorso de cada rato e fechadas por ECA e suturas (náilon 4-0). Os ratos foram observados nos dias 1, 2, 3, 7 e 15°. Os adesivos apresentaram os maiores níveis de deiscências. O etilcianoacrilato foi adequadamente tolerado neste estudo, sem induzir inflamação ou infecções, apresentando diversas vantagens de uso em relação à sutura, incluindo reduzido índice de complicações e facilitando a síntese das suturas.Palavras chaves: etil cianoacrilato; adesivos, ratos.Comparative analysis of the healing of skin wounds treated with cyanoacrylate ester adhesive (SuperBonder®) and intradermal suture with nylon in Wistar rats ABSTRACT: The ethyl-cyanoacrylate which is an acid cyanoacrilic ester of short chain it has been extensively used in cutaneous wound closure. The objective of this study was to evaluate the efficacy of ethyl cyanoacrylate in cutaneous excision repair of Wistar male rats. 16 Wister rats were used and divided in two groups, each with eight animals. The rats were premedicated with xylazine (3mg/kg IM) and ketamine (70mg/kg IM) and trichotomised manually. Antiasepsis was achieved with 70% alcohol solution and 0,5% chlorhexidine followed by placement of discarded sterile fields. A longitudinal incision was made to five centimeters on the back of each rats which were closed using ECA or sutures (4-0 nylon). The rats were observed 1st, 2nd, 3rd, 7 th, and 15th. The tissue adhesives presented the largest dehiscence levels. Ethyl cyanoacrylate was adequately tolerated in this study with no necrosis, allergic reactions, or infections. Ethyl cyanoacrylate presented several advantages over suture use, including low complication rates and aid in the suture of incisions.

Aelurostrongylosis, caused by the metastrongylid nematode Aelurostrongylus abstrusus, is an underestimated feline respiratory disease. Cats infected by A. abstrusus may show subclinical to severe clinical signs. Aelurostrongylus abstrusus has a worldwide distribution. Nevertheless, studies on this parasite in Brazil are scarce, and most have been conducted in the southern regions. This study investigated the occurrence of A. abstrusus in cats in Vilhena, Rondônia, Brazil, from April 2020 to February 2021. Three consecutive individual fecal samples from 101 cats were examined using Baermann and Hoffman tests. Two cats (1.98%) scored positive for A. abstrusus, one with the Baermann examination, and one with the Hoffman technique. No other lungworms were retrieved. The clinicopathological and epizootiological implications are described and discussed.

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