Background. Endometriosis-associated infertility (EAI) has a number of specific features, which are crucial in the choice of medical treatment. Objective. The aim of the study is to analyze endocrine profile in women with EAI before and after sclerotherapy and pregravid preparation (PP), which includes a vitamin complex FT 500 plus with inositol and vitamin D3. Methods. The study involved 70 women aged 21-40 years with endometriosis-associated infertility. The comparison group included 30 women with tuboperitoneal infertility. ELISA was used to determine concentrations of Anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone and estradiol in blood serum using a standard kit by Diagnostic Systems Laboratories, Inc (USA). During two menstrual cycles the FT 500 plus was prescribed once a day from the 2nd/3rd day of the cycle, vitamin D3 was prescribed at the dose of 2,000 IU for women without its deficiency and in therapeutic doses in case of hypovitaminosis. The sclerotherapy with 95% ethanol solution was performed on the 6th-8th day of menstrual cycle. Results. It was established that in women with EAI undergoing PP and sclerotherapy the level of AMH was lower (by 12.90%) as well as progesterone (by 9.84%), while FSH (by 14.47%), LH (by 21.14%) and estradiol (by 35.55%) was higher compare to the comparison group. At the same time, FSH (by 21.98%), LH (by 32.89%) and estradiol (by 32.23%) concentrations were significantly lower compare to their primary indices before sclerotherapy. Conclusions. Sclerotherapy and PP with a vitamin complex, inositol and vitamin D3 has a positive effect on endocrine profile in women with endometriosis-associated infertility
Introduction. According to experts, endometriosis affects 10-15% of women of reproductive age; the percentage of endometriosis-associated infertility in this category of women is 30-50%. Given that endometriosis affects women of young reproductive age, the question arises about conservative and surgical ways to restore reproductive function. Objective of the research: to analyze retrospectively the level of serum hormones of patients with endometriosis-associated infertility, depending on the type of treatment of endometrioid cysts. Materials and methods. The study included 114 women aged 21-40 years with endometriosis-associated infertility, who were treated at the "Professor S. Khmil Clinic Medical Center". The comparison group included 30 women with tuboperitoneal infertility factor. Patients with endometriosis-associated infertility were divided into 2 groups. Group 1 consisted of 54 women of reproductive age with unoperated endometrioid cysts up to 4 cm in diameter, group 2 -60 women with a medical history of surgical treatment of endometrioid cysts. Each of the groups was divided into 2 subgroups. 1a -monolateral endometrioid cysts;1b -bilateral endometrioid cysts; 2a -without recurrent cysts in the previously operated ovary; 2b -with mono-or bilateral cysts in the previously operated ovary.
The article is devoted to the current problem of endometriosis-associated infertility. In recent years, a great deal of information has been accumulated on the etiology, diagnosis and treatment of genital endometriosis and endometriosis-associated infertility. According to world studies, endometriosis remains one of the most pressing problems in modern gynecology. This is evidenced by statistics showing that the disease occurs in every 10 women of fertile age, and a total of 176 million women worldwide. Approximately 20–50 % of women included in this number have a problem of infertility. Hence, the problem of this disease is not only a medical but also a social problem. Conclusions. The tactics of treatment of patients with endometriosis who are planning a pregnancy and are included in the ART protocols are significantly different from the tactics of treatment of patients who believe that they have performed reproductive function.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.