Examination of 18 workers who had been exposed to acrylonitrile for 15.3 years on average and 18 workers who had not been exposed to acrylonitrile showed no difference in the incidence of chromosome aberrations; for each person concerned 100 metaphases were evaluated.
Chromosome aberrations and sister chromatid exchanges (SCEs) were evaluated in 27 workers with current 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) blood lipid concentrations exceeding 40 parts per trillion (ppt) and in 28 unexposed referents of similar age. No statistical differences were found between the two groups in the percentages of gaps, chromatid or chromosome exchanges, chromatid or chromosome breaks/fragments/deletions, multiple aberrations, or the overall percentage of aberrations including gaps (1.33% in the exposed group vs 1.75% in the referent group) or excluding gaps (0.54% in each group). There was an increased rate of SCEs per cell (P = 0.051) and a higher percentage of cells with more than 10 SCEs (P = 0.064) in the exposed group; however, these associations were no longer significant when smoking status was included as covariate. Additionally, neither current nor back-calculated TCDD concentration was a significant predictor of these parameters based on multiple linear and rank regression analyses.
Cytogenetic evaluation of 24 employees exposed to an average styrene concentration rate of 6.0 ppm in the laboratory, and to 58.1 ppm in the polyester processing pilot plant, has revealed no statistically significant increase in chromosome aberration rates as compared to a matched control group.
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