Chromosome investigations of workers exposed to cadmium in the manufacturing of cadmium stabilizers and pigments

Fleig, I; Rieth, H.; Stocker, W.G.; Thíess, A. M.

doi:10.1016/0147-6513(83)90054-4

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…The observed higher frequency of chromosome breaks (67.5 in exposed vs 17.5 in controls) than chromatid breaks (45 in exposed vs 0 in controls) may point to a more frequent effect of Cd prior to the phase of DNA synthesis of the cell cycle as Bui et al (1975) previously explained a same situation. In contrast to the present results, no significant increase in chromosome aberrations was reported by Fleig et al (1983) in workers exposed to dust in the manufacture of Cd pigments and stabilizers. Similarly, Forni et al (1990) proved that at high atmospheric concentration of Cd, the rate of total abnormal metaphases including gaps did not differ significantly between exposed and controls.…”

Section: Discussioncontrasting

confidence: 86%

Genotoxic effect of occupational exposure to cadmium

Abrahim¹,

Abdel-Gawad

Mahmoud

et al. 2010

Toxicol Ind Health

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Many studies proved the genotoxic effect of cadmium (Cd) exposure and highlighted the importance of the cytogenetic studies as a sensitive and effective means for early detection of Cd-induced mutagenicity. The relationship between occupational exposure to Cd and increased risk of cancer, particularly lung cancer, has been explored in number of epidemiological studies. The aim of this study is to assess the role of chromosomal abnormalities and sister chromatid exchange as sensitive indicators for the genotoxicity of occupational exposure to Cd. Cytogenetic studies was done for 40 workers (27 smokers and 13 non-smokers) exposed to Cd dust and fumes with 40 control subjects (28 smokers and 12 non-smokers) not exposed to Cd before. Both exposed and control groups were similar in age and other sociodemographic factors. Clinical examination, laboratory investigation including urinary and blood Cd, cytogenic analysis for detection of chromosomal aberrations and sister chromatid exchange and environmental study of the work places were done. Statistical analysis of cytogenetic studies revealed the presence of significant elevation of chromosomal aberrations and sister chromatid exchanges of the exposed group. Urinary and blood Cd of the exposed group were significantly higher than that of the control group. These abnormalities were not significantly affected with age, duration of exposure, smoking habits, blood and urinary Cd. In conclusion, the study adds more proof that Cd exposure has a genotoxic effect and highlighted the importance of using cytogenetic studies as a sensitive and effective means for early detection of Cd-induced mutagenicity.

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Section: Discussioncontrasting

confidence: 86%

Genotoxic effect of occupational exposure to cadmium

Abrahim¹,

Abdel-Gawad

Mahmoud

et al. 2010

Toxicol Ind Health

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“…They suggest that aberrations described previously result from a synergistic action of heavy metals with some environmental mutagens. Negative results were also recently reported by FLEIG et al (1983). GASIOREK and BAu-CHINGER (1981) have studied the in vivo effect oflead, cadmium, and zinc, separately and in combination, on the incidence of chromosomal aberrations in human lymphocytes.…”

Section: Other Effectssupporting

confidence: 60%

Effects of Cadmium Exposure in Humans

Bernard¹,

Lauwerys²

1986

Handbook of Experimental Pharmacology

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“…Thus, the dissolution of cadmium pigments and consequent release of hazardous Cd 2+ are key processes that control their potential environmental impacts. Previous risk assessments suggested that the use of cadmium pigments poses little risk to humans and the environment (except in occupational settings) due to their extremely low solubility ( K sp,CdS = 7.94 × 10 –27 and K sp,CdSe = 6.31 × 10 –36 ), and consequently low bioavailability. − Because of insufficient fate, transport, and toxicological studies, current cadmium pigment regulations are based on the precautionary principle . For example, the European Union (EU) prohibits the use of cadmium pigments in 16 plastics with exemptions (see Regulation No.…”

Section: Introductionmentioning

confidence: 99%

Sunlight Promotes Fast Release of Hazardous Cadmium from Widely-Used Commercial Cadmium Pigment

Liu

Gao

Long

et al. 2017

Environ. Sci. Technol.

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Cadmium pigments are widely used in the polymer and ceramic industry. Their potential environmental risk is under debate, being the major barrier for appropriate regulation. We show that 83.0 ± 0.2% of hazardous cadmium ion (Cd) was released from the commercial cadmium sulfoselenide pigment (i.e., cadmium red) in aqueous suspension within 24 h under simulated sunlit conditions. This photodissolution process also generated sub-20 nm pigment nanoparticles. Cd release is attributed to the reactions between photogenerated holes and the pigment lattices. The photodissolution process can be activated by both ultraviolet and visible light in the solar spectrum. Irradiation under alkaline conditions or in the presence of phosphate and carbonate species resulted in reduced charge carrier energy or the formation of insoluble and photostable cadmium precipitates on pigment surfaces, mitigating photodissolution. Tannic acid inhibited the photodissolution process by light screening and scavenging photogenerated holes. The fast release of Cd from the pigment was further confirmed in river water under natural sunlight, with 38.6 ± 0.1% of the cadmium released within 4 h. Overall, this study underscores the importance to account for photochemical effects to inform risk assessments and regulations of cadmium pigments which are currently based on their low solubility.

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Chromosome investigations of workers exposed to cadmium in the manufacturing of cadmium stabilizers and pigments

Cited by 13 publications

References 9 publications

Genotoxic effect of occupational exposure to cadmium

Genotoxic effect of occupational exposure to cadmium

Effects of Cadmium Exposure in Humans

Sunlight Promotes Fast Release of Hazardous Cadmium from Widely-Used Commercial Cadmium Pigment

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