MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

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Authentication ensures that system's resources are not obtained fraudulently by illegal users. Password authentication is one of the simplest and the most convenient authentication mechanisms over insecure networks. The problem of password authentication in an insecure networks is present in many application areas. Since computing resources have grown tremendously, password authentication is more frequently required in areas such as computer networks, wireless networks, remote login, operation systems, and database management systems. Many schemes based on cryptography have been proposed to solve the problem. However, previous schemes are vulnerable to various attacks and are neither efficient, nor user friendly. Users cannot choose and change their passwords at will. In this paper, we propose a new password authentication scheme to achieve the all proposed requirements. Furthermore, our scheme can support the Diffie-Hellman key agreement protocol over insecure networks. Users and the system can use the agreed session key to encrypt/decrypt their communicated messages using the symmetric cryptosystem. (C) 2005 Elsevier Inc. All rights reserved

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In this paper, a new Global System of Mobile Communications (GSM) authentication protocol is proposed to improve some drawbacks of the current GSM authentication protocol for roaming users including: (a) communication overhead between VLR; (b) huge bandwidth consumption between VLR and HLR; (c) storage space overhead in VLR; (d) overloaded in HLR with authentication of mobile stations; and (e) not supporting bilateral authentication. The main contribution of this paper is that it does not only improve the drawbacks listed above but also fits the needs of roaming users. In addition, the proposed protocol does not change the existing architecture of GSM, and the robustness of the proposed protocol is the same as that of the original GSM, which is based on security algorithms A3, A5, and A8