Die Pyrazolessigsäuren (VI) wurden auf zwei verschiedenen Wegen [über die Ester (IVa) bzw. über die Ketone (IVb)] dargestellt (Ausb.‐Angaben nur für die letzten Stufen: 40‐80%).
Von den für biologische Tests dargestellten Verbindungen (X) zeigt (Xa) (R2: 2,4‐F2) die stärkste antiinflammatorische Aktivität (Carra eenin‐Ödemund Adjuvans‐Arthritis‐Test an Ratten).
The preparation of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid is described. This acid has good anti-inflammatory and analgesic activities without producing irritation in the gastrointestinal tract up to the highest tested dose.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.