Pharmacology of diclofenac sodium (Voltaren®)

Scholer, Dietrich W.; Boettcher, I.; Ku, Edmond C.; Schweizer, A.

doi:10.1016/s0049-0172(85)80012-3

Cited by 6 publications

(4 citation statements)

References 1 publication

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“…aeruginosa. Many studies reported that Diclofenac sodium is a potent antiinflammatory, analgesic, anti-pyretic agent and in reducing the post-operative endodontic pain with less gastrointestinal side effects [37,38,39,40,41]. Diclofenac was found to show antibacterial effect against both grampositive and gram-negative bacteria and synergism with other antibiotics [42,43,44,45].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Mohsen¹,

Gomaa²,

Mohammed³

et al. 2015

AJEID

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Ureteral catheters are indispensable devices used in the management of ureteral obstruction. Although the stent is essential for treatment, it also has complications, which are encrustation, stone formation and biofilm formation. Biofilm infections result in a complication in the course of treatment, increasing the length of patients stay in hospital and overall cost. Catheter-associated infections are difficult to be treated with antibiotics and there is a need to change catheters due to the formation of biofilm on their surfaces. In this study, In this study, we examine the effect of some of prescribed drugs as NSAIDs and N-acetylcysteine on the adherence of S. aureus, K. pneumoniae, P. aeruginosa and Proteus mirabilis on the surface of catheters, and their effects on the preformed mature biofims. Also, we determine their antibacterial activity. The results showed that the tested agents had good antibacterial activity, a significant effect on the inhibition of adherence of the tested strains to plastic surfaces and a high disruptive effect on mature biofilms. In conclusion, the tested drugs can be used in the treatment of catheterassociated infections.

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Section: Discussionmentioning

confidence: 99%

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Mohsen¹,

Gomaa²,

Mohammed³

et al. 2015

AJEID

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“…While DCF is better tolerated than nonselective NSAIDs such as indomethacin, it is still associated with a variety of toxic small intestinal side effects. 30,31 A typical therapeutic dose of DCF (50 mg orally) translates into local concentrations between 300 and 1600 μM of DCF within the intestinal lumen (assuming an intestinal fluid volume of between 0.1 and 0.5 L). 32 Therefore, we employed a range of DCF between 500 and 1000 μM to recapitulate an intraluminal physiologically relevant concentration.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Diclofenac (2-(2,6-dichloroanilino) phenylacetic acid; DCF) has an approximately 10-fold higher preference for the COX-2 isoenzyme versus COX-1 and is primarily ingested orally, although it may also be administered via topical, intravenous, intramuscular, and intrarectal routes. While DCF is better tolerated than nonselective NSAIDs such as indomethacin, it is still associated with a variety of toxic small intestinal side effects. , A typical therapeutic dose of DCF (50 mg orally) translates into local concentrations between 300 and 1600 μM of DCF within the intestinal lumen (assuming an intestinal fluid volume of between 0.1 and 0.5 L) . Therefore, we employed a range of DCF between 500 and 1000 μM to recapitulate an intraluminal physiologically relevant concentration.…”

Section: Results and Discussionmentioning

confidence: 99%

Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

et al. 2017

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The intestinal epithelium provides a critical barrier that separates the gut microbiota from host tissues. Nonsteroidal anti-inflammatory drugs (NSAIDs) are efficacious analgesics and antipyretics and are among the most frequently used drugs worldwide. In addition to gastric damage, NSAIDs are toxic to the intestinal epithelium, causing erosions, perforations, and longitudinal ulcers in the gut. Here, we use a unique in vitro human primary small intestinal cell monolayer system to pinpoint the intestinal consequences of NSAID treatment. We found that physiologically relevant doses of the NSAID diclofenac (DCF) are cytotoxic because they uncouple mitochondrial oxidative phosphorylation and generate reactive oxygen species. We also find that DCF induces intestinal barrier permeability, facilitating the translocation of compounds from the luminal to the basolateral side of the intestinal epithelium. The results we outline here establish the utility of this novel platform, representative of the human small intestinal epithelium, to understand NSAID toxicity, which can be applied to study multiple aspects of gut barrier function including defense against infectious pathogens and host-microbiota interactions.

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“…Der Einfluß verschiedener nicht-steroidaler Antiphlogistika auf die ebenfalls am Entzündungsprozeß beteiligten Leukotriene wurde von mehreren Autoren beschrieben (7,8,26,27,28,34,35). Hierbei zeigte sich kein einheitliches Verhalten der NSAID.…”

Section: Diskussionunclassified

Prostaglandin- und Leukotrienfreisetzung aus Synovialgewebe, Knorpel und Knochen unter Therapie mit Diclofenac

Wittenberg¹,

Karger²

1993

Akt Rheumatol

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Pharmacology of diclofenac sodium (Voltaren®)

Cited by 6 publications

References 1 publication

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

Prostaglandin- und Leukotrienfreisetzung aus Synovialgewebe, Knorpel und Knochen unter Therapie mit Diclofenac

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