The discovery of novel antifungal agents with low toxicity and high therapeutic efficacy is needed to overcome the limitation of the actually existing antifungal therapies. Endophytic fungi acknowledge for their outstanding ability to produce bioactive metabolites can be exploited for this purpose. Therefore, this study was designed to investigate the antifungal potential of endophytic fungi leaving in tissues of Cola acuminata. Endophytic fungi associated with Cola acuminata were isolated from healthy and matured plant tissues and characterized based on their morphological and microscopic characters. Each isolated fungus was cultured on potato dextrose broth for ten days and crude extract prepared from the resulting medium after filtration. The resulting extracts were tested for their antifungal potential using broth microdilution method. One hundred and six fungal isolates were obtained from leaves, fruit, stem, stem bark, root, and root bark of C. acuminate. They belong to six genera including Aspergillus, Alternaria, Curvularia, Cunnighamella, Fusarium, Trichoderma. Non-sporulating isolates were designated as Mycelia. Out of the 106 extracts screened for their antifungal activities, 21, 13 and 43 showed antifungal activities against C.albicans NR-29450, C.parapsilosis ATCC 22019 and C.krusei ATCC 6258 respectively. Five of these isolates including Cal14, Casb122, Cab259, Cab31 and Cab244 were the most potent, inhibiting the growth of the three tested Candida species more than 85% against. Isolate Casb122 appears to be one of the most potent antifungal against Candida species (MIC 500-1000µg/mL). The results suggest that endophytic fungi from C. acuminata can produce metabolites with antifungal activity

The main aim of this study was to determine the quality of vegetable oils consumed by the population in Yaoundé. The study was carried out on 14 vegetable oils sampled following a survey. The antioxidant potentials of these oils were analyzed using the 2,2-diphenyl-1-picrylhydrazyl, FRAP total antioxidant capacity. The concentrations of some heavy metals (Pb, Cu, and Fe) were determined using flame atomic absorption spectrometry after acid digestion. The acid and peroxide values were assessed using methods described by the Cameroonian standard on vegetable oils. The sample included 8 brands of which, 5 of refined palm oil, 4 of soybean oil, 1 brand of cottonseed oil, sunflower oil, and cold extracted olive oil, red palm oil bleached palm oil each. The antioxidant activity showed a good correlation, with red palm oil having the greatest antioxidant potential and bleached palm oil having the least antioxidant potential. The Pb, Cu, and Fe contents had the following conformities: 71.4%, 100% respectively. For the acid and peroxide values, we found 50% and 21.4%, respectively. Six of the fourteen (42.9%) analyzed oils contained less than 33 IU/g vitamin A. These results highlight the poor quality of the oils consumed in Yaoundé.