Background and PurposeThe objective of this study was to determine the benefits of cognitive training in patients with amnestic mild cognitive impairment (aMCI) and those with early Alzheimer's disease (AD).MethodsEleven patients with aMCI and nine with early AD (stage 4 on the Global Deterioration Scale) participated in this study. Six participants with aMCI and six with AD were allocated to the cognitive training group, while five participants with aMCI and three with AD were allocated to a wait-list control group. Multicomponent cognitive training was administered in 18 weekly, individual sessions. Outcome measures were undertaken at baseline, and at 2 weeks and 3 months of follow-up.ResultsIn the trained MCI group, there were significant improvements in the delayed-recall scores on the Seoul Verbal Learning Test at both the 2-week and 3-month follow-ups compared with baseline (baseline, 1.6±1.5; 2 weeks, 4.4±1.5, p=0.04; 3 months, 4.6±2.3, p=0.04). The phonemic fluency scores (1.0±0.8 vs. 5.0±1.8, p=0.07) and Korean Mini-Mental State Examination scores (18.8±0.5 vs. 23.8±2.2, p=0.07) also showed a tendency toward improvement at the 2-week follow-up compared to baseline in the trained AD group.ConclusionsThis study provides evidence of the effectiveness of cognitive training in aMCI and early AD. The efficacy of cognitive training programs remains to be verified in studies with larger samples and a randomized design.

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This study examines how the Daedeok Science and Technology (S&T) Park, built as a national R&D center, has evolved over time from the perspective of a complex adaptive system. We argue that the Daedeok S&T Park-a planned park exhibiting pathdependent, self-reinforcing trajectories led by the government-has gradually evolved over time, undergoing some tension between nationalizing and regionalizing forces instead of encountering an imminent and radical transformation through the replication of a new model each time. The state's role is highlighted as a creator that ironically leads to the process of the planned park's evolution toward a more cluster-based park by strengthening regional actors' capabilities and changing the structure of governance. The study contributes to the literature on S&T parks by providing an in-depth analysis of an S&T park from an evolutionary perspective, and not from a typical static evaluation, and is based on archival analyses and case studies of ten firms as well as on in-depth interviews with key actors.

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